Contribution of Epstein–Barr Virus Latent Proteins to the Pathogenesis of Classical Hodgkin Lymphoma
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Institute for Cancer and Genomic Medicine, University of Birmingham, Birmingham B15 2TT, UK
2
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK
3
Department of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 775 15 Olomouc, Czech Republic
*
Authors to whom correspondence should be addressed.
Pathogens 2018, 7(3), 59; https://doi.org/10.3390/pathogens7030059
Received: 8 May 2018
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Revised: 19 June 2018
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Accepted: 20 June 2018
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Published: 27 June 2018
(This article belongs to the Special Issue Emerging Topics in Epstein-Barr virus-Associated Diseases)
Pathogenic viruses have evolved to manipulate the host cell utilising a variety of strategies including expression of viral proteins to hijack or mimic the activity of cellular functions. DNA tumour viruses often establish latent infection in which no new virions are produced, characterized by the expression of a restricted repertoire of so-called latent viral genes. These latent genes serve to remodel cellular functions to ensure survival of the virus within host cells, often for the lifetime of the infected individual. However, under certain circumstances, virus infection may contribute to transformation of the host cell; this event is not a usual outcome of infection. Here, we review how the Epstein–Barr virus (EBV), the prototypic oncogenic human virus, modulates host cell functions, with a focus on the role of the EBV latent genes in classical Hodgkin lymphoma.
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Keywords:
Epstein–Barr virus; Hodgkin lymphoma; latency; B cells
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MDPI and ACS Style
Vrzalikova, K.; Sunmonu, T.; Reynolds, G.; Murray, P. Contribution of Epstein–Barr Virus Latent Proteins to the Pathogenesis of Classical Hodgkin Lymphoma. Pathogens 2018, 7, 59. https://doi.org/10.3390/pathogens7030059
AMA Style
Vrzalikova K, Sunmonu T, Reynolds G, Murray P. Contribution of Epstein–Barr Virus Latent Proteins to the Pathogenesis of Classical Hodgkin Lymphoma. Pathogens. 2018; 7(3):59. https://doi.org/10.3390/pathogens7030059
Chicago/Turabian StyleVrzalikova, Katerina, Taofik Sunmonu, Gary Reynolds, and Paul Murray. 2018. "Contribution of Epstein–Barr Virus Latent Proteins to the Pathogenesis of Classical Hodgkin Lymphoma" Pathogens 7, no. 3: 59. https://doi.org/10.3390/pathogens7030059
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