Next Article in Journal
LBMPL Vaccine Therapy Induces Progressive Organization of the Spleen Microarchitecture, Improved Th1 Adaptative Immune Response and Control of Parasitism in Leishmania infantum Naturally Infected Dogs
Next Article in Special Issue
Genetic Diversity of Coxiella burnetii in Iran by Multi-Spacer Sequence Typing
Previous Article in Journal
Microbiota Transplantation in Day-Old Broiler Chickens Ameliorates Necrotic Enteritis via Modulation of the Intestinal Microbiota and Host Immune Responses
Previous Article in Special Issue
Leptospira interrogans Sensu Lato in Wild Small Mammals in Three Moravian Localities of the Czech Republic
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 11
Issue 9
10.3390/pathogens11090973
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Investigation of Rickettsia conorii in Patients Suspected of Having Crimean-Congo Hemorrhagic Fever

by
Neda Baseri
1,2,
Mostafa Salehi-Vaziri
3,
Ehsan Mostafavi
1,2,
Fahimeh Bagheri Amiri
1,
Mina Latifian
1,2,
John Stenos
4 and
Saber Esmaeili
1,2,*
1
Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran 1316943551, Iran
2
National Reference Laboratory for Plague, Tularemia and Q Fever, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Akanlu, KabudarAhang, Hamadan 6556153145, Iran
3
Department of Arboviruses & Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran 1316943551, Iran
4
Australian Rickettsial Reference Laboratory, University Hospital Geelong, Geelong, VIC 3220, Australia
*
Author to whom correspondence should be addressed.
Pathogens 2022, 11(9), 973; https://doi.org/10.3390/pathogens11090973
Submission received: 6 July 2022 / Revised: 20 August 2022 / Accepted: 24 August 2022 / Published: 26 August 2022
(This article belongs to the Collection Updates on Rickettsia and Coxiella)
Browse Figures
Review Reports Versions Notes

Abstract

Rickettsia conorii is the causative agent of Mediterranean spotted fever (MSF). Misdiagnosis of MSF may occur with febrile syndromes associated with rash and thrombocytopenia, such as Crimean-Congo hemorrhagic fever (CCHF). This study aimed to determine the prevalence of R. conorii among serum samples obtained from 260 suspected CCHF patients with features of MSF in Iran (2018–2020). The quantitative polymerase chain reaction (qPCR) method detected three (1.15%) positive 16S rDNA Rickettsia spp. samples that were classified as R. conorii subsp. conorii, R. conorii subsp. Israelensis, and R. helvetica using the sequencing of gltA, ompA, and 17kDa genes. Furthermore, R. conorii IgM antibodies presented in 38 (14.62%) patients by the enzyme-linked immunosorbent assay (ELISA) method. Out of 97 MSF patients with available paired serum samples, IgM seroconversion and a four-fold increase were observed in 14 (14.43%) and 12 (12.37%) patients, respectively. We concluded that rickettsial agents are present in Iran and may be misdiagnosed with other febrile syndromes.
Keywords: Mediterranean spotted fever; Rickettsia conorii; Congo-Crimean hemorrhagic fever; Rickettsia helvetica Mediterranean spotted fever; Rickettsia conorii; Congo-Crimean hemorrhagic fever; Rickettsia helvetica

Share and Cite

MDPI and ACS Style

Baseri, N.; Salehi-Vaziri, M.; Mostafavi, E.; Bagheri Amiri, F.; Latifian, M.; Stenos, J.; Esmaeili, S. Investigation of Rickettsia conorii in Patients Suspected of Having Crimean-Congo Hemorrhagic Fever. Pathogens 2022, 11, 973. https://doi.org/10.3390/pathogens11090973

AMA Style

Baseri N, Salehi-Vaziri M, Mostafavi E, Bagheri Amiri F, Latifian M, Stenos J, Esmaeili S. Investigation of Rickettsia conorii in Patients Suspected of Having Crimean-Congo Hemorrhagic Fever. Pathogens. 2022; 11(9):973. https://doi.org/10.3390/pathogens11090973

Chicago/Turabian Style

Baseri, Neda, Mostafa Salehi-Vaziri, Ehsan Mostafavi, Fahimeh Bagheri Amiri, Mina Latifian, John Stenos, and Saber Esmaeili. 2022. "Investigation of Rickettsia conorii in Patients Suspected of Having Crimean-Congo Hemorrhagic Fever" Pathogens 11, no. 9: 973. https://doi.org/10.3390/pathogens11090973

APA Style

Baseri, N., Salehi-Vaziri, M., Mostafavi, E., Bagheri Amiri, F., Latifian, M., Stenos, J., & Esmaeili, S. (2022). Investigation of Rickettsia conorii in Patients Suspected of Having Crimean-Congo Hemorrhagic Fever. Pathogens, 11(9), 973. https://doi.org/10.3390/pathogens11090973

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop