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Volume 12
Issue 7
10.3390/diagnostics12071759
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Background:
Systematic Review

Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review

by
Narcisa Muresu
1,†,
Biagio Di Lorenzo
2,†,
Laura Saderi
2,†,
Illari Sechi
1,
Arcadia Del Rio
3,
Andrea Piana
1,* and
Giovanni Sotgiu
2
1
Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy
2
Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy
3
Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Diagnostics 2022, 12(7), 1759; https://doi.org/10.3390/diagnostics12071759
Submission received: 1 June 2022 / Revised: 15 July 2022 / Accepted: 18 July 2022 / Published: 20 July 2022
(This article belongs to the Special Issue Diagnosis of Lower Genital Tract Disease)
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Abstract

The etiology of bladder cancer is known to be associated with behavioral and environmental factors. Moreover, several studies suggested a potential role of HPV infection in the pathogenesis with controversial results. A systematic review was conducted to assess the role of HPV. A total of 46 articles that reported the prevalence of HPV infection in squamous (SCC), urothelial (UC), and transitional cell carcinomas (TCC) were selected. A pooled prevalence of 19% was found, with a significant difference in SCC that was mainly driven by HPV-16. Moreover, infection prevalence in case-control studies showed a higher risk of bladder cancer in HPV-positive cases (OR: 7.84; p-value < 0.00001). The results may suggest an etiologic role of HPV in bladder cancer. HPV vaccine administration in both sexes could be key to prevent the infection caused by high-risk genotypes.
Keywords: human papillomavirus; HPV; bladder cancer; HPV detection; urothelial carcinoma; transitional cell carcinoma human papillomavirus; HPV; bladder cancer; HPV detection; urothelial carcinoma; transitional cell carcinoma

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MDPI and ACS Style

Muresu, N.; Di Lorenzo, B.; Saderi, L.; Sechi, I.; Del Rio, A.; Piana, A.; Sotgiu, G. Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review. Diagnostics 2022, 12, 1759. https://doi.org/10.3390/diagnostics12071759

AMA Style

Muresu N, Di Lorenzo B, Saderi L, Sechi I, Del Rio A, Piana A, Sotgiu G. Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review. Diagnostics. 2022; 12(7):1759. https://doi.org/10.3390/diagnostics12071759

Chicago/Turabian Style

Muresu, Narcisa, Biagio Di Lorenzo, Laura Saderi, Illari Sechi, Arcadia Del Rio, Andrea Piana, and Giovanni Sotgiu. 2022. "Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review" Diagnostics 12, no. 7: 1759. https://doi.org/10.3390/diagnostics12071759

APA Style

Muresu, N., Di Lorenzo, B., Saderi, L., Sechi, I., Del Rio, A., Piana, A., & Sotgiu, G. (2022). Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review. Diagnostics, 12(7), 1759. https://doi.org/10.3390/diagnostics12071759

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