Review Reports

Round 1

Reviewer 1 Report

This is a well conducted and written study that addresses an important question about the diagnostic utility of chromogranin A in the initial work up for a NET.

Minor queries:

1. The authors could elaborate on PIA of chromogranin A , most readers may be unaware

2. A diagram of chromogranin processing and the fragments generated may be helpful (as supplement?)

3. what would the author's recommendations be to patients who cannot discontinue PPI? Would H2 antagonists also impact on chromogranin A measurements?

4. Are there any chromogranin A byproducts that may be of interest that have better diagnostic accuracy

Author Response

Dear Reviewer

Thank you very much for the suggestions to improve the manuscript.

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

This data from single center, but from ENETS COE.

The data is from 4 years and good numbers, with good collection.

 

Author Response

Dear reviewer 2

Thank you for the appreciation of our results. 

Kind regards,

Jonas Baekdal et al.