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Life
Volume 15
Issue 8
10.3390/life15081222
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Neuroprotective Effect Against Ischemic Stroke of the Novel Functional Drink Containing Anthocyanin and Dietary Fiber Enriched-Functional Ingredient from the Mixture of Banana and Germinated Jasmine Rice

by
Mubarak Muhammad
1,
Jintanaporn Wattanathorn
2,3,*,
Wipawee Thukham-mee
2,3,
Sophida Phuthong
2,3 and
Supaporn Muchimapura
2,3
1
Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
2
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
3
Research Institute for High Human Performance and Health Promotion, Khon Kaen University, Khon Kaen 40002, Thailand
*
Author to whom correspondence should be addressed.
Life 2025, 15(8), 1222; https://doi.org/10.3390/life15081222 (registering DOI)
Submission received: 7 June 2025 / Revised: 23 July 2025 / Accepted: 25 July 2025 / Published: 2 August 2025
(This article belongs to the Special Issue Bioactive Compounds for Medicine and Health)
Versions Notes

Abstract

Due to the stroke-protective effects of dietary fiber and anthocyanin together with the synergistic interaction, we hypothesized that the functional drink containing the anthocyanins and dietary fiber-enriched functional ingredient from banana and germinated black Jasmine rice (BR) should protect against ischemic stroke. BR at doses of 300, 600, and 900 mg/kg body weight (BW) was orally given to male Wistar rats weighing 290–350 g once daily for 21 days, and they were subjected to ischemic reperfusion injury induced by temporary occlusion of the middle cerebral artery (MCAO/IR) for 90 min. The treatment was prolonged for 21 days after MCAO/IR. They were assessed for brain infarction volume, neuron density, Nrf2, MDA, and catalase in the cortex together with serum TNF-α and IL-6. Lactobacillus and Bifidobacterium spp. in feces were also assessed. Our results showed that BR improved the increase in brain infarcted volume, MDA, TNF-α, and IL-6 and the decrease in neuron density, Nrf2, catalase, and both bacteria spp. induced by MCAO/IR. These data suggest the stroke-protective effect of the novel functional drink, and the action may involve the improvement of Nrf2, oxidative stress, inflammation, and the amount of Lactobacillus and Bifidobacterium spp.
Keywords: ischemic stroke; anthocyanin; dietary fiber; banana; black Jasmine rice ischemic stroke; anthocyanin; dietary fiber; banana; black Jasmine rice

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MDPI and ACS Style

Muhammad, M.; Wattanathorn, J.; Thukham-mee, W.; Phuthong, S.; Muchimapura, S. Neuroprotective Effect Against Ischemic Stroke of the Novel Functional Drink Containing Anthocyanin and Dietary Fiber Enriched-Functional Ingredient from the Mixture of Banana and Germinated Jasmine Rice. Life 2025, 15, 1222. https://doi.org/10.3390/life15081222

AMA Style

Muhammad M, Wattanathorn J, Thukham-mee W, Phuthong S, Muchimapura S. Neuroprotective Effect Against Ischemic Stroke of the Novel Functional Drink Containing Anthocyanin and Dietary Fiber Enriched-Functional Ingredient from the Mixture of Banana and Germinated Jasmine Rice. Life. 2025; 15(8):1222. https://doi.org/10.3390/life15081222

Chicago/Turabian Style

Muhammad, Mubarak, Jintanaporn Wattanathorn, Wipawee Thukham-mee, Sophida Phuthong, and Supaporn Muchimapura. 2025. "Neuroprotective Effect Against Ischemic Stroke of the Novel Functional Drink Containing Anthocyanin and Dietary Fiber Enriched-Functional Ingredient from the Mixture of Banana and Germinated Jasmine Rice" Life 15, no. 8: 1222. https://doi.org/10.3390/life15081222

APA Style

Muhammad, M., Wattanathorn, J., Thukham-mee, W., Phuthong, S., & Muchimapura, S. (2025). Neuroprotective Effect Against Ischemic Stroke of the Novel Functional Drink Containing Anthocyanin and Dietary Fiber Enriched-Functional Ingredient from the Mixture of Banana and Germinated Jasmine Rice. Life, 15(8), 1222. https://doi.org/10.3390/life15081222

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