Rat Animal Model of Pectus Excavatum
Abstract
:1. Introduction
2. Materials and Methods
2.1. The Animals
2.2. Surgical Procedure
2.3. CT Scan, Assessment
2.4. Direct Assessment and Measurements of the Thoracic Cage
2.5. Statistical Analysis
3. Results
3.1. Assessment on CT Images
3.2. Direct Assessment and Measurements of the Thoracic Cage
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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CT1 (Preoperative) | CT2 (7 Days) | CT3 (14 Days) | CT4 (21 Days) | CT5 (28 Days) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
CG | EG | CG | EG | CG | EG | CG | EG | CG | EG | |
AD (mm) | 29.12 ± 1.08 | 28.24 ± 2.03 | 31.76 ± 1.95 | 31.50 ± 1.79 | 35.62 ± 0.56 | 36.27 ± 1.00 | 38.80 ± 0.84 | 38.38 ± 1.24 | 40.56 ± 1.00 | 40.08 ± 1.54 |
p = 0.39 | p = 0.80 | p = 0.20 | p = 0.51 | p = 0.55 | ||||||
SSD (mm) | 4.77 ± 0.14 | 4.95 ± 0.29 | 5.09 ± 0.24 | 5.24 ± 0.28 | 5.54 ± 0.18 | 5.65 ± 0.35 | 5.77 ± 0.27 | 6.12 ± 0.24 | 6.00 ± 0.22 | 6.71 ± 0.42 |
p = 0.24 | p = 0.33 | p = 0.53 | p = 0.35 | p = 0.01 | ||||||
SD4 (mm) | 8.63 ± 0.44 | 8.57 ± 0.48 | 10.61 ± 0.28 | 10.93 ± 0.90 | 12.04 ± 0.45 | 11.08 ± 0.78 | 12.72 ± 0.64 | 12.72 ± 0.92 | 13.92 ± 0.63 | 13.76 ± 0.65 |
p = 0.81 | p = 0.47 | p = 0.02 | p = 0.99 | p = 0.67 | ||||||
ISD (mm) | 17.28 ± 0.58 | 16.71 ± 1.16 | 24.48 ± 0.74 | 18.80 ± 3.14 | 28.46 ± 2.54 | 19.54 ± 2.00 | 30.10 ± 0.45 | 20.95 ± 2.25 | 30.18 ± 0.57 | 22.78 ± 2.12 |
p = 0.33 | p = 0.02 | p = 0.00 | p = 0.00 | p = 0.00 | ||||||
STD (mm) | 6.92 ± 0.12 | 6.84 ± 0.22 | 7.12 ± 0.09 | 7.52 ± 0.37 | 7.30 ± 0.21 | 7.76 ± 0.56 | 7.92 ± 0.14 | 8.29 ± 0.42 | 8.54 ± 0.37 | 8.45 ± 0.54 |
p = 0.373 | p = 0.03 | p = 0.10 | p = 0.08 | p = 0.73 | ||||||
TD4 (mm) | 15.12 ± 0.68 | 14.52 ± 0.90 | 17.56 ± 0.40 | 17.52 ± 0.99 | 19.96 ± 0.38 | 19.30 ± 1.30 | 21.36 ± 0.48 | 20.72 ± 0.87 | 22.64 ± 0.34 | 22.18 ± 0.80 |
p =0.19 | p = 0.92 | p = 0.29 | p = 0.13 | p = 0.34 | ||||||
ITD (mm) | 24.82 ± 0.30 | 24.13 ± 1.32 | 28.94 ± 0.70 | 27.65 ± 1.61 | 31.16 ± 0.38 | 29.63 ± 1.20 | 32.66 ± 0.92 | 30.35 ± 1.50 | 32.98 ± 0.32 | 31.95 ± 1.21 |
p = 0.28 | p = 0.12 | p = 0.19 | p = 0.01 | p = 0.09 |
CT1 (Preoperative) | CT2 (7 Days Postop) | CT3 (14 Days Postop) | CT4 (21 Days Postop) | CT5 (28 Days Postop) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
CG | EG | CG | EG | CG | EG | CG | EG | CG | EG | |
SHI | 1.45 ± 0.02 | 1.38 ± 0.03 | 1.40 ± 0.08 | 1.44 ± 0.12 | 1.31 ± 0.08 | 1.38 ± 0.17 | 1.37 ± 0.07 | 1.35 ± 0.07 | 1.42 ± 0.09 | 1.26 ± 0.11 |
p = 0.03 | p = 0.49 | p = 0.38 | p = 0.68 | p = 0.02 | ||||||
HI4 | 1.75 ± 0.07 | 1.61 ± 0.13 | 1.65 ± 0.07 | 1.61 ± 0.14 | 1.65 ± 0.07 | 1.74 ± 0.14 | 1.68 ± 0.07 | 1.63 ± 0.12 | 1.62 ± 0.03 | 1.61 ± 0.08 |
p = 0.22 | p = 0.52 | p = 0.16 | p = 0.41 | p = 0.70 | ||||||
IHI | 1.43 ± 0.03 | 1.50 ± 0.10 | 1.18 ± 0.04 | 1.49 ± 0.23 | 1.10 ± 0.10 | 1.49 ± 0.23 | 1.08 ± 0.04 | 1.46 ± 0.15 | 1.16 ± 0.10 | 1.41 ± 0.11 |
p = 0.20 | p = 0.03 | p = 0.00 | p = 0.00 | p = 0.04 |
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David, V.-L.; Ciornei, B.; Horhat, F.-G.; Amaricai, E.; Horhat, I.-D.; Hoinoiu, T.; Boia, E.-S. Rat Animal Model of Pectus Excavatum. Life 2020, 10, 96. https://doi.org/10.3390/life10060096
David V-L, Ciornei B, Horhat F-G, Amaricai E, Horhat I-D, Hoinoiu T, Boia E-S. Rat Animal Model of Pectus Excavatum. Life. 2020; 10(6):96. https://doi.org/10.3390/life10060096
Chicago/Turabian StyleDavid, Vlad-Laurentiu, Bogdan Ciornei, Florin-George Horhat, Elena Amaricai, Ioana-Delia Horhat, Teodora Hoinoiu, and Eugen-Sorin Boia. 2020. "Rat Animal Model of Pectus Excavatum" Life 10, no. 6: 96. https://doi.org/10.3390/life10060096