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Antibodies, Volume 2, Issue 4

December 2013 - 5 articles

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Articles (5)

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Review

8 Citations

9,381 Views

19 Pages

Potential for Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity for Control of Human Cytomegalovirus

Rebecca J. Aicheler,
Eddie C. Y. Wang,
Peter Tomasec,
Gavin W. G. Wilkinson and
Richard J. Stanton

Antibodies2013, 2(4), 617-635;https://doi.org/10.3390/antib2040617

10 December 2013

Human cytomegalovirus (HCMV) is an important pathogen that infects the majority of the population worldwide, yet, currently, there is no licensed vaccine. Despite HCMV encoding at least seven Natural Killer (NK) cell evasion genes, NK cells remain cr...

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Article

13 Citations

8,596 Views

19 Pages

CD20 mAb-Mediated Complement Dependent Cytotoxicity of Tumor Cells is Enhanced by Blocking the Action of Factor I

Margaret A. Lindorfer,
Paul V. Beum and
Ronald P. Taylor

Antibodies2013, 2(4), 598-616;https://doi.org/10.3390/antib2040598

28 November 2013

The CD20 mAbs, rituximab (RTX) and ofatumumab (OFA), have been used with success in the clinic in the treatment of B cell malignancies. These mAbs can eliminate B cells only by utilizing the body’s immune effector mechanisms, and there is considerabl...

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Review

5 Citations

8,320 Views

11 Pages

Regulatory B-Cells in Transplantation

David San Segundo,
Marcos López-Hoyos and
Manuel Arias

Antibodies2013, 2(4), 587-597;https://doi.org/10.3390/antib2040587

20 November 2013

B-cells have been long accepted as the main cellular component in humoral responses. Their effector function is based on antibody and cytokine production. The development of donor-specific antibodies by B-cells has deleterious consequences in graft a...

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Review

3 Citations

17,994 Views

33 Pages

Regulation of Germinal Center Reactions by B and T Cells

Young Uk Kim,
Xindong Liu,
Shinya Tanaka,
Dat Quoc Tran and
Yeonseok Chung

Antibodies2013, 2(4), 554-586;https://doi.org/10.3390/antib2040554

23 October 2013

Break of B cell tolerance to self-antigens results in the development of autoantibodies and, thus, leads to autoimmunity. How B cell tolerance is maintained during active germinal center (GC) reactions is yet to be fully understood. Recent advances r...

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Review

19 Citations

23,150 Views

19 Pages

Communication between B-Cells and Microbiota for the Maintenance of Intestinal Homeostasis

Yuying Liu and
Jon Marc Rhoads

Antibodies2013, 2(4), 535-553;https://doi.org/10.3390/antib2040535

17 October 2013

The human intestine is populated with an extremely dense and diverse bacterial community. Commensal bacteria act as an important antigenic stimulus producing the maturation of gut-associated lymphoid tissue (GALT). The production of immunoglobulin (I...

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