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Genes 2018, 9(12), 634; https://doi.org/10.3390/genes9120634

Regulation of Structure-Specific Endonucleases in Replication Stress

Program in Molecular & Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
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Received: 9 November 2018 / Revised: 11 December 2018 / Accepted: 12 December 2018 / Published: 14 December 2018
(This article belongs to the Special Issue Chromosome Replication and Genome Integrity)
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Abstract

Replication stress results in various forms of aberrant replication intermediates that need to be resolved for faithful chromosome segregation. Structure-specific endonucleases (SSEs) recognize DNA secondary structures rather than primary sequences and play key roles during DNA repair and replication stress. Holliday junction resolvase MUS81 (methyl methane sulfonate (MMS), and UV-sensitive protein 81) and XPF (xeroderma pigmentosum group F-complementing protein) are a subset of SSEs that resolve aberrant replication structures. To ensure genome stability and prevent unnecessary DNA breakage, these SSEs are tightly regulated by the cell cycle and replication checkpoints. We discuss the regulatory network that control activities of MUS81 and XPF and briefly mention other SSEs involved in the resolution of replication intermediates. View Full-Text
Keywords: replication stress; structure-specific endonuclease; Mus81; XPF replication stress; structure-specific endonuclease; Mus81; XPF
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Kim, S.M.; Forsburg, S.L. Regulation of Structure-Specific Endonucleases in Replication Stress. Genes 2018, 9, 634.

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