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Modeling and Targeting MYC Genes in Childhood Brain Tumors

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden
Author to whom correspondence should be addressed.
Academic Editor: Daitoku Sakamuro
Genes 2017, 8(4), 107;
Received: 2 February 2017 / Revised: 14 March 2017 / Accepted: 16 March 2017 / Published: 23 March 2017
(This article belongs to the Special Issue MYC Networks)
PDF [1626 KB, uploaded 29 March 2017]


Brain tumors are the second most common group of childhood cancers, accounting for about 20%–25% of all pediatric tumors. Deregulated expression of the MYC family of transcription factors, particularly c-MYC and MYCN genes, has been found in many of these neoplasms, and their expression levels are often correlated with poor prognosis. Elevated c-MYC/MYCN initiates and drives tumorigenesis in many in vivo model systems of pediatric brain tumors. Therefore, inhibition of their oncogenic function is an attractive therapeutic target. In this review, we explore the roles of MYC oncoproteins and their molecular targets during the formation, maintenance, and recurrence of childhood brain tumors. We also briefly summarize recent progress in the development of therapeutic approaches for pharmacological inhibition of MYC activity in these tumors. View Full-Text
Keywords: MYC; oncogene; pediatric brain tumors; targeted therapy; medulloblastoma; glioma MYC; oncogene; pediatric brain tumors; targeted therapy; medulloblastoma; glioma

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Hutter, S.; Bolin, S.; Weishaupt, H.; Swartling, F.J. Modeling and Targeting MYC Genes in Childhood Brain Tumors. Genes 2017, 8, 107.

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