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Genes 2017, 8(11), 330;

The HMGA1 Pseudogene 7 Induces miR-483 and miR-675 Upregulation by Activating Egr1 through a ceRNA Mechanism

Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli “Federico II”, via Pansini, 5, 80131 Naples, Italy
Istituto Nazionale dei Tumori, Fondazione Pascale, via Mariano Semmola, 52, 80131 Naples, Italy
IRCCS Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124 Bari, Italy
Author to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 8 November 2017 / Accepted: 9 November 2017 / Published: 17 November 2017
(This article belongs to the Special Issue Non-coding RNAs)
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Several studies have established that pseudogene mRNAs can work as competing endogenous RNAs and, when deregulated, play a key role in the onset of human neoplasias. Recently, we have isolated two HMGA1 pseudogenes, HMGA1P6 and HMGA1P7. These pseudogenes have a critical role in cancer progression, acting as micro RNA (miRNA) sponges for HMGA1 and other cancer-related genes. HMGA1 pseudogenes were found overexpressed in several human carcinomas, and their expression levels positively correlate with an advanced cancer stage and a poor prognosis. In order to investigate the molecular alterations following HMGA1 pseudogene 7 overexpression, we carried out miRNA sequencing analysis on HMGA1P7 overexpressing mouse embryonic fibroblasts. Intriguingly, the most upregulated miRNAs were miR-483 and miR-675 that have been described as key regulators in cancer progression. Here, we report that HMGA1P7 upregulates miR-483 and miR-675 through a competing endogenous RNA mechanism with Egr1, a transcriptional factor that positively regulates miR-483 and miR-675 expression. View Full-Text
Keywords: HMGA1 pseudogenes; HMGA1P7; micro RNA; ceRNA HMGA1 pseudogenes; HMGA1P7; micro RNA; ceRNA

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De Martino, M.; Palma, G.; Azzariti, A.; Arra, C.; Fusco, A.; Esposito, F. The HMGA1 Pseudogene 7 Induces miR-483 and miR-675 Upregulation by Activating Egr1 through a ceRNA Mechanism. Genes 2017, 8, 330.

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