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Super-Resolution Microscopy of Chromatin

1
University of Applied Sciences HTW Chur, Pulvermühlestrasse 57, 7004 Chur, Switzerland
2
Institut für Physik, Universität Mainz, 55128 Mainz, Germany
Genes 2019, 10(7), 493; https://doi.org/10.3390/genes10070493
Received: 16 May 2019 / Revised: 17 June 2019 / Accepted: 26 June 2019 / Published: 28 June 2019
(This article belongs to the Special Issue 3D Genomics)
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Abstract

Since the advent of super-resolution microscopy, countless approaches and studies have been published contributing significantly to our understanding of cellular processes. With the aid of chromatin-specific fluorescence labeling techniques, we are gaining increasing insight into gene regulation and chromatin organization. Combined with super-resolution imaging and data analysis, these labeling techniques enable direct assessment not only of chromatin interactions but also of the function of specific chromatin conformational states. View Full-Text
Keywords: chromatin; super-resolution microscopy; nuclear architecture; single molecule localization microscopy; DNA; fluorescence; DNA labeling chromatin; super-resolution microscopy; nuclear architecture; single molecule localization microscopy; DNA; fluorescence; DNA labeling
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Birk, U.J. Super-Resolution Microscopy of Chromatin. Genes 2019, 10, 493.

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