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m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins

Laboratoire de Biochimie, Ecole polytechnique, CNRS, Université Paris-Saclay, 91128 Palaiseau CEDEX, France
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Genes 2019, 10(1), 49; https://doi.org/10.3390/genes10010049
Received: 10 December 2018 / Revised: 8 January 2019 / Accepted: 10 January 2019 / Published: 15 January 2019
(This article belongs to the Special Issue RNA Modifications)
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Abstract

The control of gene expression is a multi-layered process occurring at the level of DNA, RNA, and proteins. With the emergence of highly sensitive techniques, new aspects of RNA regulation have been uncovered leading to the emerging field of epitranscriptomics dealing with RNA modifications. Among those post-transcriptional modifications, N6-methyladenosine (m6A) is the most prevalent in messenger RNAs (mRNAs). This mark can either prevent or stimulate the formation of RNA-protein complexes, thereby influencing mRNA-related mechanisms and cellular processes. This review focuses on proteins containing a YTH domain (for YT521-B Homology), a small building block, that selectively detects the m6A nucleotide embedded within a consensus motif. Thereby, it contributes to the recruitment of various effectors involved in the control of mRNA fates through adjacent regions present in the different YTH-containing proteins. View Full-Text
Keywords: epitranscriptomics; mRNA methylation; m6A readers; YTH domain epitranscriptomics; mRNA methylation; m6A readers; YTH domain
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Hazra, D.; Chapat, C.; Graille, M. m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins. Genes 2019, 10, 49.

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