Next Article in Journal
Progress in the Analysis of Food Allergens through Molecular Biology Approaches
Next Article in Special Issue
mTOR Regulation of Metabolism in Hematologic Malignancies
Previous Article in Journal
Hyaluronan Accelerates Intestinal Mucosal Healing through Interaction with TSG-6
Previous Article in Special Issue
Eribulin Synergistically Increases Anti-Tumor Activity of an mTOR Inhibitor by Inhibiting pAKT/pS6K/pS6 in Triple Negative Breast Cancer

Roles of mTOR Signaling in Tissue Regeneration

Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China
Authors to whom correspondence should be addressed.
Cells 2019, 8(9), 1075;
Received: 9 August 2019 / Revised: 6 September 2019 / Accepted: 7 September 2019 / Published: 12 September 2019
(This article belongs to the Special Issue mTOR Signaling in Metabolism and Cancer)
The mammalian target of rapamycin (mTOR), is a serine/threonine protein kinase and belongs to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family. mTOR interacts with other subunits to form two distinct complexes, mTORC1 and mTORC2. mTORC1 coordinates cell growth and metabolism in response to environmental input, including growth factors, amino acid, energy and stress. mTORC2 mainly controls cell survival and migration through phosphorylating glucocorticoid-regulated kinase (SGK), protein kinase B (Akt), and protein kinase C (PKC) kinase families. The dysregulation of mTOR is involved in human diseases including cancer, cardiovascular diseases, neurodegenerative diseases, and epilepsy. Tissue damage caused by trauma, diseases or aging disrupt the tissue functions. Tissue regeneration after injuries is of significance for recovering the tissue homeostasis and functions. Mammals have very limited regenerative capacity in multiple tissues and organs, such as the heart and central nervous system (CNS). Thereby, understanding the mechanisms underlying tissue regeneration is crucial for tissue repair and regenerative medicine. mTOR is activated in multiple tissue injuries. In this review, we summarize the roles of mTOR signaling in tissue regeneration such as neurons, muscles, the liver and the intestine. View Full-Text
Keywords: mTOR signaling; metabolism; tissue regeneration; neuron; muscle; liver; intestine mTOR signaling; metabolism; tissue regeneration; neuron; muscle; liver; intestine
Show Figures

Figure 1

MDPI and ACS Style

Wei, X.; Luo, L.; Chen, J. Roles of mTOR Signaling in Tissue Regeneration. Cells 2019, 8, 1075.

AMA Style

Wei X, Luo L, Chen J. Roles of mTOR Signaling in Tissue Regeneration. Cells. 2019; 8(9):1075.

Chicago/Turabian Style

Wei, Xiangyong, Lingfei Luo, and Jinzi Chen. 2019. "Roles of mTOR Signaling in Tissue Regeneration" Cells 8, no. 9: 1075.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop