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Review

Roles of mTOR Signaling in Tissue Regeneration

Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China
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Authors to whom correspondence should be addressed.
Cells 2019, 8(9), 1075; https://doi.org/10.3390/cells8091075
Received: 9 August 2019 / Revised: 6 September 2019 / Accepted: 7 September 2019 / Published: 12 September 2019
(This article belongs to the Special Issue mTOR Signaling in Metabolism and Cancer)
The mammalian target of rapamycin (mTOR), is a serine/threonine protein kinase and belongs to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family. mTOR interacts with other subunits to form two distinct complexes, mTORC1 and mTORC2. mTORC1 coordinates cell growth and metabolism in response to environmental input, including growth factors, amino acid, energy and stress. mTORC2 mainly controls cell survival and migration through phosphorylating glucocorticoid-regulated kinase (SGK), protein kinase B (Akt), and protein kinase C (PKC) kinase families. The dysregulation of mTOR is involved in human diseases including cancer, cardiovascular diseases, neurodegenerative diseases, and epilepsy. Tissue damage caused by trauma, diseases or aging disrupt the tissue functions. Tissue regeneration after injuries is of significance for recovering the tissue homeostasis and functions. Mammals have very limited regenerative capacity in multiple tissues and organs, such as the heart and central nervous system (CNS). Thereby, understanding the mechanisms underlying tissue regeneration is crucial for tissue repair and regenerative medicine. mTOR is activated in multiple tissue injuries. In this review, we summarize the roles of mTOR signaling in tissue regeneration such as neurons, muscles, the liver and the intestine. View Full-Text
Keywords: mTOR signaling; metabolism; tissue regeneration; neuron; muscle; liver; intestine mTOR signaling; metabolism; tissue regeneration; neuron; muscle; liver; intestine
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MDPI and ACS Style

Wei, X.; Luo, L.; Chen, J. Roles of mTOR Signaling in Tissue Regeneration. Cells 2019, 8, 1075. https://doi.org/10.3390/cells8091075

AMA Style

Wei X, Luo L, Chen J. Roles of mTOR Signaling in Tissue Regeneration. Cells. 2019; 8(9):1075. https://doi.org/10.3390/cells8091075

Chicago/Turabian Style

Wei, Xiangyong, Lingfei Luo, and Jinzi Chen. 2019. "Roles of mTOR Signaling in Tissue Regeneration" Cells 8, no. 9: 1075. https://doi.org/10.3390/cells8091075

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