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Roles of mTOR Signaling in Tissue Regeneration
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mTOR Regulation of Metabolism in Hematologic Malignancies

Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy
Hematology, “Sant’ Andrea” University Hospital, Sapienza University of Rome, 00185 Rome, Italy
Author to whom correspondence should be addressed.
Cells 2020, 9(2), 404;
Received: 6 December 2019 / Revised: 2 February 2020 / Accepted: 7 February 2020 / Published: 11 February 2020
(This article belongs to the Special Issue mTOR Signaling in Metabolism and Cancer)
Neoplastic cells rewire their metabolism, acquiring a selective advantage over normal cells and a protection from therapeutic agents. The mammalian Target of Rapamycin (mTOR) is a serine/threonine kinase involved in a variety of cellular activities, including the control of metabolic processes. mTOR is hyperactivated in a large number of tumor types, and among them, in many hematologic malignancies. In this article, we summarized the evidence from the literature that describes a central role for mTOR in the acquisition of new metabolic phenotypes for different hematologic malignancies, in concert with other metabolic modulators (AMPK, HIF1α) and microenvironmental stimuli, and shows how these features can be targeted for therapeutic purposes.
Keywords: mTOR; hematologic malignancies; cell metabolism mTOR; hematologic malignancies; cell metabolism
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MDPI and ACS Style

Mirabilii, S.; Ricciardi, M.R.; Tafuri, A. mTOR Regulation of Metabolism in Hematologic Malignancies. Cells 2020, 9, 404.

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