The Role of Nuclear Receptors in Prostate Cancer
1
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
2
Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan
*
Author to whom correspondence should be addressed.
Cells 2019, 8(6), 602; https://doi.org/10.3390/cells8060602
Received: 30 May 2019
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Revised: 12 June 2019
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Accepted: 13 June 2019
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Published: 17 June 2019
(This article belongs to the Collection Functions of Nuclear Receptors)
The nuclear receptor (NR) superfamily consists of 48 members that are divided into seven subfamilies. NRs are transcription factors that play an important role in a number of biological processes. The NR superfamily includes androgen receptor, which is a key player in prostate cancer pathogenesis, suggesting the functional roles of other NRs in prostate cancer. The findings on the roles of NRs in prostate cancer thus far have shown that several NRs such as vitamin D receptor, estrogen receptor β, and mineralocorticoid receptor play antioncogenic roles, while other NRs such as peroxisome proliferator-activated receptor γ and estrogen receptor α as well as androgen receptor play oncogenic roles. However, the roles of other NRs in prostate cancer remain controversial or uninvestigated. Further research on the role of NRs in prostate cancer is required and may lead to the development of novel preventions and therapeutics for prostate cancer.
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Keywords:
androgen receptor; estrogen receptor; glucocorticoid receptor; mineralocorticoid receptor; nuclear receptor; progesterone receptor; prostate cancer; steroid receptor
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MDPI and ACS Style
Shiota, M.; Fujimoto, N.; Kashiwagi, E.; Eto, M. The Role of Nuclear Receptors in Prostate Cancer. Cells 2019, 8, 602. https://doi.org/10.3390/cells8060602
AMA Style
Shiota M, Fujimoto N, Kashiwagi E, Eto M. The Role of Nuclear Receptors in Prostate Cancer. Cells. 2019; 8(6):602. https://doi.org/10.3390/cells8060602
Chicago/Turabian StyleShiota, Masaki, Naohiro Fujimoto, Eiji Kashiwagi, and Masatoshi Eto. 2019. "The Role of Nuclear Receptors in Prostate Cancer" Cells 8, no. 6: 602. https://doi.org/10.3390/cells8060602
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