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Open AccessReview

Importance of the Androgen Receptor Signaling in Gene Transactivation and Transrepression for Pubertal Maturation of the Testis

1
Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE) - CONICET – FEI - División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires C1425EFD, Argentina
2
Departamento de Biología Celular, Histología, Embriología y Genética, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina
*
Authors to whom correspondence should be addressed.
Cells 2019, 8(8), 861; https://doi.org/10.3390/cells8080861
Received: 1 July 2019 / Revised: 30 July 2019 / Accepted: 1 August 2019 / Published: 9 August 2019
(This article belongs to the Special Issue Functions of Nuclear Receptors)
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PDF [2056 KB, uploaded 9 August 2019]
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Abstract

Androgens are key for pubertal development of the mammalian testis, a phenomenon that is tightly linked to Sertoli cell maturation. In this review, we discuss how androgen signaling affects Sertoli cell function and morphology by concomitantly inhibiting some processes and promoting others that contribute jointly to the completion of spermatogenesis. We focus on the molecular mechanisms that underlie anti-Müllerian hormone (AMH) inhibition by androgens at puberty, as well as on the role androgens have on Sertoli cell tight junction formation and maintenance and, consequently, on its effect on proper germ cell differentiation and meiotic onset during spermatogenesis. View Full-Text
Keywords: Sertoli; meiosis; AMH; blood-testis barrier; spermatogenesis Sertoli; meiosis; AMH; blood-testis barrier; spermatogenesis
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Edelsztein, N.Y.; Rey, R.A. Importance of the Androgen Receptor Signaling in Gene Transactivation and Transrepression for Pubertal Maturation of the Testis. Cells 2019, 8, 861.

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