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Review

RhoGTPase in Vascular Disease

by
Derek Strassheim
1,
Evgenia Gerasimovskaya
1,2,
David Irwin
1,
Edward C. Dempsey
1,3,4,
Kurt Stenmark
1,2 and
Vijaya Karoor
1,3,*
1
Cardiovascular and Pulmonary Research Lab, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
2
Department of Pediatrics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
3
Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
4
Rocky Mountain Regional VA Medical Center, Aurora, CO 80045, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(6), 551; https://doi.org/10.3390/cells8060551
Submission received: 18 March 2019 / Revised: 24 May 2019 / Accepted: 27 May 2019 / Published: 6 June 2019
(This article belongs to the Collection Rho GTPases in Health and Disease)
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Abstract

Ras-homologous (Rho)A/Rho-kinase pathway plays an essential role in many cellular functions, including contraction, motility, proliferation, and apoptosis, inflammation, and its excessive activity induces oxidative stress and promotes the development of cardiovascular diseases. Given its role in many physiological and pathological functions, targeting can result in adverse effects and limit its use for therapy. In this review, we have summarized the role of RhoGTPases with an emphasis on RhoA in vascular disease and its impact on endothelial, smooth muscle, and heart and lung fibroblasts. It is clear from the various studies that understanding the regulation of RhoGTPases and their regulators in physiology and pathological conditions is required for effective targeting of Rho.
Keywords: RhoGTPases; endothelial; smooth muscle; fibroblasts; vascular; therapeutics RhoGTPases; endothelial; smooth muscle; fibroblasts; vascular; therapeutics
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MDPI and ACS Style

Strassheim, D.; Gerasimovskaya, E.; Irwin, D.; Dempsey, E.C.; Stenmark, K.; Karoor, V. RhoGTPase in Vascular Disease. Cells 2019, 8, 551. https://doi.org/10.3390/cells8060551

AMA Style

Strassheim D, Gerasimovskaya E, Irwin D, Dempsey EC, Stenmark K, Karoor V. RhoGTPase in Vascular Disease. Cells. 2019; 8(6):551. https://doi.org/10.3390/cells8060551

Chicago/Turabian Style

Strassheim, Derek, Evgenia Gerasimovskaya, David Irwin, Edward C. Dempsey, Kurt Stenmark, and Vijaya Karoor. 2019. "RhoGTPase in Vascular Disease" Cells 8, no. 6: 551. https://doi.org/10.3390/cells8060551

APA Style

Strassheim, D., Gerasimovskaya, E., Irwin, D., Dempsey, E. C., Stenmark, K., & Karoor, V. (2019). RhoGTPase in Vascular Disease. Cells, 8(6), 551. https://doi.org/10.3390/cells8060551

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