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Spatiotemporal Regulation of Rho GTPases in Neuronal Migration

1
The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, Guangdong, China
2
Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen 518057, Guangdong, China
*
Author to whom correspondence should be addressed.
Cells 2019, 8(6), 568; https://doi.org/10.3390/cells8060568
Received: 28 April 2019 / Revised: 1 June 2019 / Accepted: 4 June 2019 / Published: 10 June 2019
(This article belongs to the Special Issue Rho GTPases in Health and Disease)
Neuronal migration is essential for the orchestration of brain development and involves several contiguous steps: interkinetic nuclear movement (INM), multipolar–bipolar transition, locomotion, and translocation. Growing evidence suggests that Rho GTPases, including RhoA, Rac, Cdc42, and the atypical Rnd members, play critical roles in neuronal migration by regulating both actin and microtubule cytoskeletal components. This review focuses on the spatiotemporal-specific regulation of Rho GTPases as well as their regulators and effectors in distinct steps during the neuronal migration process. Their roles in bridging extracellular signals and cytoskeletal dynamics to provide optimal structural support to the migrating neurons will also be discussed. View Full-Text
Keywords: Rho GTPase; guanine nucleotide exchange factor; GTPase-activating protein; neuronal migration; neuronal development Rho GTPase; guanine nucleotide exchange factor; GTPase-activating protein; neuronal migration; neuronal development
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MDPI and ACS Style

Xu, Z.; Chen, Y.; Chen, Y. Spatiotemporal Regulation of Rho GTPases in Neuronal Migration. Cells 2019, 8, 568.

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