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Review

Strategies to Circumvent Host Innate Immune Response by Hepatitis C Virus

by 1, 2 and 1,3,*
1
Departments of Internal Medicine, Saint Louis University, St. Louis, MO 63104, USA
2
Departments of Pathology, Saint Louis University, St. Louis, MO 63104, USA
3
Molecular Microbiology & Immunology, Saint Louis University, St. Louis, MO 63104, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(3), 274; https://doi.org/10.3390/cells8030274
Received: 4 January 2019 / Revised: 15 March 2019 / Accepted: 18 March 2019 / Published: 22 March 2019
(This article belongs to the Special Issue Hepatitis C Virus and Host Interactions)
Innate immune responses generate interferons, proinflammatory cytokines, complement activation, and natural killer (NK) cell response. Ultimately, this leads to the induction of a robust virus-specific adaptive immunity. Although the host innate immune system senses and responds to eliminate virus infection, hepatitis C virus (HCV) evades immune attack and establishes persistent infection within the liver. Spontaneous clearance of HCV infection is associated with a prompt induction of innate immunity generated in an infected host. In this review, we have highlighted the current knowledge of our understanding of host–HCV interactions, especially for endogenous interferon production, proinflammatory response, NK cell response, and complement activation, which may impair the generation of a strong adaptive immune response for establishment of chronicity. The information may provide novel strategies in augmenting therapeutic intervention against HCV. View Full-Text
Keywords: hepatitis C virus; innate immunity; interferon; cytokine; NK cell; complement hepatitis C virus; innate immunity; interferon; cytokine; NK cell; complement
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MDPI and ACS Style

Patra, T.; Ray, R.B.; Ray, R. Strategies to Circumvent Host Innate Immune Response by Hepatitis C Virus. Cells 2019, 8, 274. https://doi.org/10.3390/cells8030274

AMA Style

Patra T, Ray RB, Ray R. Strategies to Circumvent Host Innate Immune Response by Hepatitis C Virus. Cells. 2019; 8(3):274. https://doi.org/10.3390/cells8030274

Chicago/Turabian Style

Patra, Tapas, Ratna B. Ray, and Ranjit Ray. 2019. "Strategies to Circumvent Host Innate Immune Response by Hepatitis C Virus" Cells 8, no. 3: 274. https://doi.org/10.3390/cells8030274

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