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Review

Yeast to Study Human Purine Metabolism Diseases

1
Université de Bordeaux IBGC UMR 5095 1, rue Camille Saint-Saëns, F-33077 Bordeaux, France
2
Centre National de la Recherche Scientifique IBGC UMR 5095 1, rue Camille Saint-Saëns, F-33077 Bordeaux, France
*
Author to whom correspondence should be addressed.
Cells 2019, 8(1), 67; https://doi.org/10.3390/cells8010067
Received: 8 January 2019 / Revised: 15 January 2019 / Accepted: 15 January 2019 / Published: 17 January 2019
Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences. Accordingly, several genetic disorders associated with defective purine metabolism have been reported. The etiology of these diseases is poorly understood and simple model organisms, such as yeast, have proved valuable to provide a more comprehensive view of the metabolic consequences caused by the identified mutations. In this review, we present results obtained with the yeast Saccharomyces cerevisiae to exemplify how a eukaryotic unicellular organism can offer highly relevant information for identifying the molecular basis of complex human diseases. Overall, purine metabolism illustrates a remarkable conservation of genes, functions and phenotypes between humans and yeast. View Full-Text
Keywords: purine metabolism; nucleotide synthesis; purine-associated deficiencies; hyperuricemia; Lesch–Nyhan; AMP-deaminase; ATIC; ADSL; PRPS purine metabolism; nucleotide synthesis; purine-associated deficiencies; hyperuricemia; Lesch–Nyhan; AMP-deaminase; ATIC; ADSL; PRPS
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MDPI and ACS Style

Daignan-Fornier, B.; Pinson, B. Yeast to Study Human Purine Metabolism Diseases. Cells 2019, 8, 67. https://doi.org/10.3390/cells8010067

AMA Style

Daignan-Fornier B, Pinson B. Yeast to Study Human Purine Metabolism Diseases. Cells. 2019; 8(1):67. https://doi.org/10.3390/cells8010067

Chicago/Turabian Style

Daignan-Fornier, Bertrand; Pinson, Benoît. 2019. "Yeast to Study Human Purine Metabolism Diseases" Cells 8, no. 1: 67. https://doi.org/10.3390/cells8010067

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