Next Article in Journal
Retinal Neuron Is More Sensitive to Blue Light-Induced Damage than Glia Cell Due to DNA Double-Strand Breaks
Next Article in Special Issue
Recent Insights into NCL Protein Function Using the Model Organism Dictyostelium discoideum
Previous Article in Journal
Adhesion Deregulation in Acute Myeloid Leukaemia
Previous Article in Special Issue
Recent Advances in CRISPR/Cas9-Mediated Genome Editing in Dictyostelium
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Cells 2019, 8(1), 67; https://doi.org/10.3390/cells8010067

Yeast to Study Human Purine Metabolism Diseases

1
Université de Bordeaux IBGC UMR 5095 1, rue Camille Saint-Saëns, F-33077 Bordeaux, France
2
Centre National de la Recherche Scientifique IBGC UMR 5095 1, rue Camille Saint-Saëns, F-33077 Bordeaux, France
*
Author to whom correspondence should be addressed.
Received: 8 January 2019 / Revised: 15 January 2019 / Accepted: 15 January 2019 / Published: 17 January 2019
Full-Text   |   PDF [891 KB, uploaded 17 January 2019]   |  

Abstract

Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences. Accordingly, several genetic disorders associated with defective purine metabolism have been reported. The etiology of these diseases is poorly understood and simple model organisms, such as yeast, have proved valuable to provide a more comprehensive view of the metabolic consequences caused by the identified mutations. In this review, we present results obtained with the yeast Saccharomyces cerevisiae to exemplify how a eukaryotic unicellular organism can offer highly relevant information for identifying the molecular basis of complex human diseases. Overall, purine metabolism illustrates a remarkable conservation of genes, functions and phenotypes between humans and yeast. View Full-Text
Keywords: purine metabolism; nucleotide synthesis; purine-associated deficiencies; hyperuricemia; Lesch–Nyhan; AMP-deaminase; ATIC; ADSL; PRPS purine metabolism; nucleotide synthesis; purine-associated deficiencies; hyperuricemia; Lesch–Nyhan; AMP-deaminase; ATIC; ADSL; PRPS
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Daignan-Fornier, B.; Pinson, B. Yeast to Study Human Purine Metabolism Diseases. Cells 2019, 8, 67.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top