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Cells 2018, 7(8), 93; https://doi.org/10.3390/cells7080093

The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications

1
Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver V5Z 1L3, BC, Canada
2
Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver V6T 1Z4, BC, Canada
*
Author to whom correspondence should be addressed.
Received: 9 July 2018 / Revised: 27 July 2018 / Accepted: 29 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue Regulatory microRNA)
Full-Text   |   PDF [818 KB, uploaded 2 August 2018]   |  

Abstract

Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound structures that play key roles in intercellular communication. EVs are potent regulators of tumorigenesis and function largely via the shuttling of cargo molecules (RNA, DNA, protein, etc.) among cancer cells and the cells of the tumor stroma. EV-based crosstalk can promote proliferation, shape the tumor microenvironment, enhance metastasis, and allow tumor cells to evade immune destruction. In many cases these functions have been linked to the presence of specific cargo molecules. Herein we will review various types of EV cargo molecule and their functional impacts in the context of oncology. View Full-Text
Keywords: extracellular vesicles; cancer; therapeutics extracellular vesicles; cancer; therapeutics
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Jabalee, J.; Towle, R.; Garnis, C. The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications. Cells 2018, 7, 93.

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