Correction: Savtchenko, L.P.; Rusakov, D.A. Glutamate–Transporter Unbinding in Probabilistic Synaptic Environment Facilitates Activation of Distant NMDA Receptors. Cells 2023, 12, 1610

In the original publication [1], there was an error in Figure 1D that was caused by a misprint—the corrected values were not automatically saved in the PDF file. The time labels should be corrected as follows: instead of 0.3 ms, 1.0 ms, and 3.0 ms, they should read 0.6 ms, 2.0 ms, and 6.0 ms, respectively, in both graphs. The correct Figure appears below:

Figure 1. Simulating extrasynaptic glutamate escape and transporter binding and unbinding using a stochastic model of probabilistic synaptic environment. (A) Diagram depicting the extracellular space filled with overlapping spheroids representing neuronal (light green) and astroglial (light magenta) structures, with an extracellular space volume fraction α = 0.2, and an astroglial volume fraction VF_astro = 0.1; the ring illustrates approximately the extent of the synaptic cleft (with two hemispheric obstacles representing pre- and postsynaptic elements [33]); and a tissue fragment (2 × 2 × 1 μm³ slab of the 4 × 4 × 4 μm³ simulation arena) is shown for presentation clarity. (B) The average spatial profile of iGluSnFR fluorescence (green) with respect to the glutamate release site (zero distance) near an individual CA3-CA1 synapse at its peak post-release, as recorded earlier [26], and the average profile (mean ± SEM, n = 10) of the simulated transporter-bound glutamate concentration (blue) at 4 ms post-release, for Ψ = 1 ms, as indicated. (C) Diagram as in A, but shown, for clarity, with astroglial transporter-bound (red) and free (blue) glutamate molecules (1000 particles, 1 ms post-release) using three presentations: as a space slab similar to A (left); with astroglial elements only (centre); and as a 2 × 2 × 2 μm³ arena filled with both neuronal and astroglial elements (right). (D) Simulated spatial profiles of free glutamate concentration at various time points post-release, as indicated, with no transporter unbinding (left) and with unbinding at a probability P_unbind = 0.35 (right).

Figure 1. Simulating extrasynaptic glutamate escape and transporter binding and unbinding using a stochastic model of probabilistic synaptic environment. (A) Diagram depicting the extracellular space filled with overlapping spheroids representing neuronal (light green) and astroglial (light magenta) structures, with an extracellular space volume fraction α = 0.2, and an astroglial volume fraction VF_astro = 0.1; the ring illustrates approximately the extent of the synaptic cleft (with two hemispheric obstacles representing pre- and postsynaptic elements [33]); and a tissue fragment (2 × 2 × 1 μm³ slab of the 4 × 4 × 4 μm³ simulation arena) is shown for presentation clarity. (B) The average spatial profile of iGluSnFR fluorescence (green) with respect to the glutamate release site (zero distance) near an individual CA3-CA1 synapse at its peak post-release, as recorded earlier [26], and the average profile (mean ± SEM, n = 10) of the simulated transporter-bound glutamate concentration (blue) at 4 ms post-release, for Ψ = 1 ms, as indicated. (C) Diagram as in A, but shown, for clarity, with astroglial transporter-bound (red) and free (blue) glutamate molecules (1000 particles, 1 ms post-release) using three presentations: as a space slab similar to A (left); with astroglial elements only (centre); and as a 2 × 2 × 2 μm³ arena filled with both neuronal and astroglial elements (right). (D) Simulated spatial profiles of free glutamate concentration at various time points post-release, as indicated, with no transporter unbinding (left) and with unbinding at a probability P_unbind = 0.35 (right).

The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.