Next Article in Journal
A Beginner’s Guide to Cell Culture: Practical Advice for Preventing Needless Problems
Next Article in Special Issue
An Efficient Humanized Mouse Model for Oral Anti-Retroviral Administration
Previous Article in Journal
Microbiological Aspects of Pharmaceutical Manufacturing of Adipose-Derived Stem Cell-Based Medicinal Products
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 12
Issue 5
10.3390/cells12050681
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia

by
Rosa Calvello
1,†,
Chiara Porro
2,†,
Dario Domenico Lofrumento
3,
Melania Ruggiero
1,
Maria Antonietta Panaro
1,* and
Antonia Cianciulli
1
1
Department of Biosciences, Biotechnologies and Environment, University of Bari, I-70125 Bari, Italy
2
Department of Clinical and Experimental Medicine, University of Foggia, I-71100 Foggia, Italy
3
Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2023, 12(5), 681; https://doi.org/10.3390/cells12050681
Submission received: 17 January 2023 / Revised: 17 February 2023 / Accepted: 20 February 2023 / Published: 21 February 2023
(This article belongs to the Special Issue Therapeutic Mechanism of Nervous System Inflammation)
Browse Figures
Versions Notes

Abstract

Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer’s (AD) and Parkinson’s diseases (PD). In the present study, we report that the treatment of activated microglia with resveratrol after prolonged exposure to lipopolysaccharide is not only able to modulate pro-inflammatory responses, but it also up-regulates the expression of decoy receptors, IL-1R2 and ACKR2 (atypical chemokine receptors), also known as negative regulatory receptors, which are able to reduce the functional responses promoting the resolution of inflammation. This result might constitute a hitherto unknown anti-inflammatory mechanism exerted by resveratrol on activated microglia.
Keywords: microglia; resveratrol; decoy receptors; lipopolysaccharide; cytokines microglia; resveratrol; decoy receptors; lipopolysaccharide; cytokines

Share and Cite

MDPI and ACS Style

Calvello, R.; Porro, C.; Lofrumento, D.D.; Ruggiero, M.; Panaro, M.A.; Cianciulli, A. Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia. Cells 2023, 12, 681. https://doi.org/10.3390/cells12050681

AMA Style

Calvello R, Porro C, Lofrumento DD, Ruggiero M, Panaro MA, Cianciulli A. Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia. Cells. 2023; 12(5):681. https://doi.org/10.3390/cells12050681

Chicago/Turabian Style

Calvello, Rosa, Chiara Porro, Dario Domenico Lofrumento, Melania Ruggiero, Maria Antonietta Panaro, and Antonia Cianciulli. 2023. "Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia" Cells 12, no. 5: 681. https://doi.org/10.3390/cells12050681

APA Style

Calvello, R., Porro, C., Lofrumento, D. D., Ruggiero, M., Panaro, M. A., & Cianciulli, A. (2023). Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia. Cells, 12(5), 681. https://doi.org/10.3390/cells12050681

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop