Next Article in Journal
Hallmarks and Molecular Tools for the Study of Mitophagy in Parkinson’s Disease
Previous Article in Journal
Regeneration or Repair? The Role of Alveolar Epithelial Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF)
Previous Article in Special Issue
Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis
 
 
Review

Mechanisms of Sperm–Egg Interactions: What Ascidian Fertilization Research Has Taught Us

by 1,2,* and 3,4,*
1
Department of Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Nagoya 463-8521, Japan
2
Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan
3
Department of Applied Life Sciences, Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan
4
Shizuoka Institute for the Study of Marine Biology and Chemistry, Shizuoka University, Shizuoka 422-8529, Japan
*
Authors to whom correspondence should be addressed.
Academic Editors: Peter Sutovsky and Michal Zigo
Cells 2022, 11(13), 2096; https://doi.org/10.3390/cells11132096
Received: 3 April 2022 / Revised: 18 June 2022 / Accepted: 28 June 2022 / Published: 1 July 2022
Fertilization is an essential process in terrestrial organisms for creating a new organism with genetic diversity. Before gamete fusion, several steps are required to achieve successful fertilization. Animal spermatozoa are first activated and attracted to the eggs by egg-derived chemoattractants. During the sperm passage of the egg’s extracellular matrix or upon the sperm binding to the proteinaceous egg coat, the sperm undergoes an acrosome reaction, an exocytosis of acrosome. In hermaphrodites such as ascidians, the self/nonself recognition process occurs when the sperm binds to the egg coat. The activated or acrosome-reacted spermatozoa penetrate through the proteinaceous egg coat. The extracellular ubiquitin–proteasome system, the astacin-like metalloproteases, and the trypsin-like proteases play key roles in this process in ascidians. In the present review, we summarize our current understanding and perspectives on gamete recognition and egg coat lysins in ascidians and consider the general mechanisms of fertilization in animals and plants. View Full-Text
Keywords: sperm; fertilization; ubiquitin; proteasome; metalloprotease; lysin; self/nonself recognition; ascidian sperm; fertilization; ubiquitin; proteasome; metalloprotease; lysin; self/nonself recognition; ascidian
Show Figures

Figure 1

MDPI and ACS Style

Sawada, H.; Saito, T. Mechanisms of Sperm–Egg Interactions: What Ascidian Fertilization Research Has Taught Us. Cells 2022, 11, 2096. https://doi.org/10.3390/cells11132096

AMA Style

Sawada H, Saito T. Mechanisms of Sperm–Egg Interactions: What Ascidian Fertilization Research Has Taught Us. Cells. 2022; 11(13):2096. https://doi.org/10.3390/cells11132096

Chicago/Turabian Style

Sawada, Hitoshi, and Takako Saito. 2022. "Mechanisms of Sperm–Egg Interactions: What Ascidian Fertilization Research Has Taught Us" Cells 11, no. 13: 2096. https://doi.org/10.3390/cells11132096

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop