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Review

Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis

by 1, 2,3 and 1,4,*
1
Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University, 718 East Haizhou Rd, Haining 314400, China
2
Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, School of Medicine, Zhejiang University, Sir Run Run Shaw Hospital, 3 East Qing Chun Rd, Hangzhou 310020, China
3
College of Life Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310058, China
4
Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310029, China
*
Author to whom correspondence should be addressed.
Academic Editors: Peter Sutovsky, Michal Zigo and Alexander E. Kalyuzhny
Cells 2022, 11(6), 1058; https://doi.org/10.3390/cells11061058
Received: 28 January 2022 / Revised: 14 March 2022 / Accepted: 18 March 2022 / Published: 21 March 2022
Spermatogenesis is a prolonged and highly ordered physiological process that produces haploid male germ cells through more than 40 steps and experiences dramatic morphological and cellular transformations. The ubiquitin proteasome system (UPS) plays central roles in the precise control of protein homeostasis to ensure the effectiveness of certain protein groups at a given stage and the inactivation of them after this stage. Many UPS components have been demonstrated to regulate the progression of spermatogenesis at different levels. Especially in recent years, novel testis-specific proteasome isoforms have been identified to be essential and unique for spermatogenesis. In this review, we set out to discuss our current knowledge in functions of diverse USP components in mammalian spermatogenesis through: (1) the composition of proteasome isoforms at each stage of spermatogenesis; (2) the specificity of each proteasome isoform and the associated degradation events; (3) the E3 ubiquitin ligases mediating protein ubiquitination in male germ cells; and (4) the deubiquitinases involved in spermatogenesis and male fertility. Exploring the functions of UPS machineries in spermatogenesis provides a global picture of the proteome dynamics during male germ cell production and shed light on the etiology and pathogenesis of human male infertility. View Full-Text
Keywords: proteasome; ubiquitination; E3 ubiquitin ligase; deubiquitinating enzyme (DUB); spermatogenesis; meiosis proteasome; ubiquitination; E3 ubiquitin ligase; deubiquitinating enzyme (DUB); spermatogenesis; meiosis
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MDPI and ACS Style

Xiong, Y.; Yu, C.; Zhang, Q. Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis. Cells 2022, 11, 1058. https://doi.org/10.3390/cells11061058

AMA Style

Xiong Y, Yu C, Zhang Q. Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis. Cells. 2022; 11(6):1058. https://doi.org/10.3390/cells11061058

Chicago/Turabian Style

Xiong, Yi, Chao Yu, and Qianting Zhang. 2022. "Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis" Cells 11, no. 6: 1058. https://doi.org/10.3390/cells11061058

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