Next Article in Journal
Comprehensive Characterization of Multitissue Expression Landscape, Co-Expression Networks and Positive Selection in Pikeperch
Next Article in Special Issue
Efferocytosis during Skeletal Muscle Regeneration
Previous Article in Journal
Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation
Review

Adipose Tissue Immunometabolism and Apoptotic Cell Clearance

Institute of Neurobiology, Ulm University, Albert-Einstein-Allee 1, 89081 Ulm, Germany
Academic Editor: Zsuzsa Szondy
Cells 2021, 10(9), 2288; https://doi.org/10.3390/cells10092288
Received: 12 August 2021 / Revised: 26 August 2021 / Accepted: 30 August 2021 / Published: 2 September 2021
The safe removal of apoptotic debris by macrophages—often referred to as efferocytosis—is crucial for maintaining tissue integrity and preventing self-immunity or tissue damaging inflammation. Macrophages clear tissues of hazardous materials from dying cells and ultimately adopt a pro-resolving activation state. However, adipocyte apoptosis is an inflammation-generating process, and the removal of apoptotic adipocytes by so-called adipose tissue macrophages triggers a sequence of events that lead to meta-inflammation and obesity-associated metabolic diseases. Signals that allow apoptotic cells to control macrophage immune functions are complex and involve metabolites released by the apoptotic cells and also metabolites produced by the macrophages during the digestion of apoptotic cell contents. This review provides a concise summary of the adipocyte-derived metabolites that potentially control adipose tissue macrophage immune functions and, hence, may induce or alleviate adipose tissue inflammation. View Full-Text
Keywords: apoptosis; obesity; meta-inflammation; immunometabolism; macrophage; M2 macrophage; efferocytosis; phagocytosis apoptosis; obesity; meta-inflammation; immunometabolism; macrophage; M2 macrophage; efferocytosis; phagocytosis
Show Figures

Figure 1

MDPI and ACS Style

Röszer, T. Adipose Tissue Immunometabolism and Apoptotic Cell Clearance. Cells 2021, 10, 2288. https://doi.org/10.3390/cells10092288

AMA Style

Röszer T. Adipose Tissue Immunometabolism and Apoptotic Cell Clearance. Cells. 2021; 10(9):2288. https://doi.org/10.3390/cells10092288

Chicago/Turabian Style

Röszer, Tamás. 2021. "Adipose Tissue Immunometabolism and Apoptotic Cell Clearance" Cells 10, no. 9: 2288. https://doi.org/10.3390/cells10092288

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop