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10.3390/cells10071700
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Article

Bemisia tabaci Vesicle-Associated Membrane Protein 2 Interacts with Begomoviruses and Plays a Role in Virus Acquisition

by
Yun-Yun Fan
1,
Yu-Wei Zhong
1,
Jing Zhao
1,
Yao Chi
1,
Sophie Bouvaine
2,
Shu-Sheng Liu
1,
Susan E. Seal
2,* and
Xiao-Wei Wang
1,*
1
Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China
2
Natural Resources Institute, University of Greenwich, Chatham, Kent ME4 4TB, UK
*
Authors to whom correspondence should be addressed.
Cells 2021, 10(7), 1700; https://doi.org/10.3390/cells10071700
Submission received: 29 April 2021 / Revised: 29 June 2021 / Accepted: 29 June 2021 / Published: 5 July 2021
(This article belongs to the Collection Plant-Virus/Viroid-Vector Interactions)
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Abstract

Begomoviruses cause substantial losses to agricultural production, especially in tropical and subtropical regions, and are exclusively transmitted by members of the whitefly Bemisia tabaci species complex. However, the molecular mechanisms underlying the transmission of begomoviruses by their whitefly vector are not clear. In this study, we found that B. tabaci vesicle-associated membrane protein 2 (BtVAMP2) interacts with the coat protein (CP) of tomato yellow leaf curl virus (TYLCV), an emergent begomovirus that seriously impacts tomato production globally. After infection with TYLCV, the transcription of BtVAMP2 was increased. When the BtVAMP2 protein was blocked by feeding with a specific BtVAMP2 antibody, the quantity of TYLCV in B. tabaci whole body was significantly reduced. BtVAMP2 was found to be conserved among the B. tabaci species complex and also interacts with the CP of Sri Lankan cassava mosaic virus (SLCMV). When feeding with BtVAMP2 antibody, the acquisition quantity of SLCMV in whitefly whole body was also decreased significantly. Overall, our results demonstrate that BtVAMP2 interacts with the CP of begomoviruses and promotes their acquisition by whitefly.
Keywords: acquisition; begomovirus; coat proteins; SLCMV; TYLCV; transmission; VAMP2; whitefly acquisition; begomovirus; coat proteins; SLCMV; TYLCV; transmission; VAMP2; whitefly

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MDPI and ACS Style

Fan, Y.-Y.; Zhong, Y.-W.; Zhao, J.; Chi, Y.; Bouvaine, S.; Liu, S.-S.; Seal, S.E.; Wang, X.-W. Bemisia tabaci Vesicle-Associated Membrane Protein 2 Interacts with Begomoviruses and Plays a Role in Virus Acquisition. Cells 2021, 10, 1700. https://doi.org/10.3390/cells10071700

AMA Style

Fan Y-Y, Zhong Y-W, Zhao J, Chi Y, Bouvaine S, Liu S-S, Seal SE, Wang X-W. Bemisia tabaci Vesicle-Associated Membrane Protein 2 Interacts with Begomoviruses and Plays a Role in Virus Acquisition. Cells. 2021; 10(7):1700. https://doi.org/10.3390/cells10071700

Chicago/Turabian Style

Fan, Yun-Yun, Yu-Wei Zhong, Jing Zhao, Yao Chi, Sophie Bouvaine, Shu-Sheng Liu, Susan E. Seal, and Xiao-Wei Wang. 2021. "Bemisia tabaci Vesicle-Associated Membrane Protein 2 Interacts with Begomoviruses and Plays a Role in Virus Acquisition" Cells 10, no. 7: 1700. https://doi.org/10.3390/cells10071700

APA Style

Fan, Y.-Y., Zhong, Y.-W., Zhao, J., Chi, Y., Bouvaine, S., Liu, S.-S., Seal, S. E., & Wang, X.-W. (2021). Bemisia tabaci Vesicle-Associated Membrane Protein 2 Interacts with Begomoviruses and Plays a Role in Virus Acquisition. Cells, 10(7), 1700. https://doi.org/10.3390/cells10071700

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