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Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions

by 1,* and 1,2,*
1
Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
2
Department of Science of Allergy and Inflammation, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Yoshimichi Okayama
Cells 2021, 10(7), 1697; https://doi.org/10.3390/cells10071697
Received: 7 June 2021 / Revised: 30 June 2021 / Accepted: 2 July 2021 / Published: 5 July 2021
(This article belongs to the Special Issue Mast Cells in Health and Diseases)
The recent emergence of anti-immunoglobulin E (IgE) drugs and their candidates for humans has endorsed the significance of IgE-dependent pathways in allergic disorders. IgE is distributed locally in the tissues or systemically to confer a sensory mechanism in a domain of adaptive immunity to the otherwise innate type of effector cells, namely, mast cells and basophils. Bound on the high-affinity IgE receptor FcεRI, IgE enables fast memory responses against revisiting threats of venoms, parasites, and bacteria. However, the dysregulation of IgE-dependent reactions leads to potentially life-threatening allergic diseases, such as asthma and anaphylaxis. Therefore, reactivity of the IgE sensor is fine-tuned by various IgE-associating molecules. In this review, we discuss the mechanistic basis for how IgE-dependent mast cell activation is regulated by the IgE-associating molecules, including the newly developed therapeutic candidates. View Full-Text
Keywords: IgE; mast cells; basophils; FcεRI; CD23; histamine-releasing factor (HRF); glycosylation; structure; omalizumab IgE; mast cells; basophils; FcεRI; CD23; histamine-releasing factor (HRF); glycosylation; structure; omalizumab
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MDPI and ACS Style

Ando, T.; Kitaura, J. Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions. Cells 2021, 10, 1697. https://doi.org/10.3390/cells10071697

AMA Style

Ando T, Kitaura J. Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions. Cells. 2021; 10(7):1697. https://doi.org/10.3390/cells10071697

Chicago/Turabian Style

Ando, Tomoaki, and Jiro Kitaura. 2021. "Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions" Cells 10, no. 7: 1697. https://doi.org/10.3390/cells10071697

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