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Review

Neuroprotective Natural Products for Alzheimer’s Disease

1
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC 27506, USA
2
Department of Pharmaceutical and Administrative Sciences, School of Pharmacy, Presbyterian College, Clinton, SC 29325, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Pyotr A. Slominsky
Cells 2021, 10(6), 1309; https://doi.org/10.3390/cells10061309
Received: 21 April 2021 / Revised: 17 May 2021 / Accepted: 22 May 2021 / Published: 25 May 2021
(This article belongs to the Special Issue Advances in Neurodegenerative Disease)
Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and in the pharmaceutical industry for their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of natural products from different origins have been evaluated preclinically and clinically for their neuroprotective mechanisms in preventing and attenuating the multifactorial pathologies of AD. This review mainly focuses on the possible neuroprotective mechanisms from natural products that may be beneficial in AD treatment and the natural product mixtures or extracts from different sources that have demonstrated neuroprotective activity in preclinical and/or clinical studies. It is believed that natural product mixtures or extracts containing multiple bioactive compounds that can work additively or synergistically to exhibit multiple neuroprotective mechanisms might be an effective approach in AD drug discovery. View Full-Text
Keywords: Alzheimer’s disease (AD); neurodegenerative; neuroprotective; natural products; antioxidant; anti-neuroinflammatory; amyloid β peptide (Aβ); neurofibrillary tangles (NFTs) Alzheimer’s disease (AD); neurodegenerative; neuroprotective; natural products; antioxidant; anti-neuroinflammatory; amyloid β peptide (Aβ); neurofibrillary tangles (NFTs)
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MDPI and ACS Style

Chen, X.; Drew, J.; Berney, W.; Lei, W. Neuroprotective Natural Products for Alzheimer’s Disease. Cells 2021, 10, 1309. https://doi.org/10.3390/cells10061309

AMA Style

Chen X, Drew J, Berney W, Lei W. Neuroprotective Natural Products for Alzheimer’s Disease. Cells. 2021; 10(6):1309. https://doi.org/10.3390/cells10061309

Chicago/Turabian Style

Chen, Xin, Joshua Drew, Wren Berney, and Wei Lei. 2021. "Neuroprotective Natural Products for Alzheimer’s Disease" Cells 10, no. 6: 1309. https://doi.org/10.3390/cells10061309

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