Next Article in Journal
The Role of Protein Arginine Methylation as Post-Translational Modification on Actin Cytoskeletal Components in Neuronal Structure and Function
Next Article in Special Issue
EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor
Previous Article in Journal
Endothelial and Vascular Health: A Tale of Honey, H2O2 and Calcium
Previous Article in Special Issue
Zebrafish Models of Autosomal Recessive Ataxias
Review

The Role of Lipids, Lipid Metabolism and Ectopic Lipid Accumulation in Axon Growth, Regeneration and Repair after CNS Injury and Disease

by 1 and 1,2,*
1
Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA
2
Discovery Theme on Chronic Brain Injury, The Ohio State University, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Antón Barreiro-Iglesias
Cells 2021, 10(5), 1078; https://doi.org/10.3390/cells10051078
Received: 23 March 2021 / Revised: 20 April 2021 / Accepted: 27 April 2021 / Published: 1 May 2021
(This article belongs to the Special Issue Axon Regeneration)
Axons in the adult mammalian nervous system can extend over formidable distances, up to one meter or more in humans. During development, axonal and dendritic growth requires continuous addition of new membrane. Of the three major kinds of membrane lipids, phospholipids are the most abundant in all cell membranes, including neurons. Not only immature axons, but also severed axons in the adult require large amounts of lipids for axon regeneration to occur. Lipids also serve as energy storage, signaling molecules and they contribute to tissue physiology, as demonstrated by a variety of metabolic disorders in which harmful amounts of lipids accumulate in various tissues through the body. Detrimental changes in lipid metabolism and excess accumulation of lipids contribute to a lack of axon regeneration, poor neurological outcome and complications after a variety of central nervous system (CNS) trauma including brain and spinal cord injury. Recent evidence indicates that rewiring lipid metabolism can be manipulated for therapeutic gain, as it favors conditions for axon regeneration and CNS repair. Here, we review the role of lipids, lipid metabolism and ectopic lipid accumulation in axon growth, regeneration and CNS repair. In addition, we outline molecular and pharmacological strategies to fine-tune lipid composition and energy metabolism in neurons and non-neuronal cells that can be exploited to improve neurological recovery after CNS trauma and disease. View Full-Text
Keywords: lipids; axon growth and regeneration; mitochondria transport; myelin formation; adipose tissue; CNS trauma and disease lipids; axon growth and regeneration; mitochondria transport; myelin formation; adipose tissue; CNS trauma and disease
Show Figures

Figure 1

MDPI and ACS Style

Roy, D.; Tedeschi, A. The Role of Lipids, Lipid Metabolism and Ectopic Lipid Accumulation in Axon Growth, Regeneration and Repair after CNS Injury and Disease. Cells 2021, 10, 1078. https://doi.org/10.3390/cells10051078

AMA Style

Roy D, Tedeschi A. The Role of Lipids, Lipid Metabolism and Ectopic Lipid Accumulation in Axon Growth, Regeneration and Repair after CNS Injury and Disease. Cells. 2021; 10(5):1078. https://doi.org/10.3390/cells10051078

Chicago/Turabian Style

Roy, Debasish, and Andrea Tedeschi. 2021. "The Role of Lipids, Lipid Metabolism and Ectopic Lipid Accumulation in Axon Growth, Regeneration and Repair after CNS Injury and Disease" Cells 10, no. 5: 1078. https://doi.org/10.3390/cells10051078

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop