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Zebrafish Models of Autosomal Dominant Ataxias
Open AccessReview

Zebrafish Models of Autosomal Recessive Ataxias

1
Department of Zoology, Genetics and Physical Anthropology, Faculty of Veterinary Science, Universidade de Santiago de Compostela, 27002 Lugo, Spain
2
Department of Functional Biology, CIBUS, Faculty of Biology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
3
Instituto de Investigación Biomédica de A Coruña (INIBIC), Servicio Galego de Saúde, 15006 A Coruña, Spain
4
Preclinical Animal Models Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
Current address: Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.
These authors contributed equally to the manuscript.
Academic Editor: Sylvie Schneider-Maunoury
Cells 2021, 10(4), 836; https://doi.org/10.3390/cells10040836
Received: 9 March 2021 / Revised: 1 April 2021 / Accepted: 6 April 2021 / Published: 8 April 2021
(This article belongs to the Special Issue Axon Regeneration)
Autosomal recessive ataxias are much less well studied than autosomal dominant ataxias and there are no clearly defined systems to classify them. Autosomal recessive ataxias, which are characterized by neuronal and multisystemic features, have significant overlapping symptoms with other complex multisystemic recessive disorders. The generation of animal models of neurodegenerative disorders increases our knowledge of their cellular and molecular mechanisms and helps in the search for new therapies. Among animal models, the zebrafish, which shares 70% of its genome with humans, offer the advantages of being small in size and demonstrating rapid development, making them optimal for high throughput drug and genetic screening. Furthermore, embryo and larval transparency allows to visualize cellular processes and central nervous system development in vivo. In this review, we discuss the contributions of zebrafish models to the study of autosomal recessive ataxias characteristic phenotypes, behavior, and gene function, in addition to commenting on possible treatments found in these models. Most of the zebrafish models generated to date recapitulate the main features of recessive ataxias. View Full-Text
Keywords: zebrafish; hereditary recessive ataxias; neurodegenerative disorders; genetic edition zebrafish; hereditary recessive ataxias; neurodegenerative disorders; genetic edition
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MDPI and ACS Style

Quelle-Regaldie, A.; Sobrido-Cameán, D.; Barreiro-Iglesias, A.; Sobrido, M.J.; Sánchez, L. Zebrafish Models of Autosomal Recessive Ataxias. Cells 2021, 10, 836. https://doi.org/10.3390/cells10040836

AMA Style

Quelle-Regaldie A, Sobrido-Cameán D, Barreiro-Iglesias A, Sobrido MJ, Sánchez L. Zebrafish Models of Autosomal Recessive Ataxias. Cells. 2021; 10(4):836. https://doi.org/10.3390/cells10040836

Chicago/Turabian Style

Quelle-Regaldie, Ana; Sobrido-Cameán, Daniel; Barreiro-Iglesias, Antón; Sobrido, María J.; Sánchez, Laura. 2021. "Zebrafish Models of Autosomal Recessive Ataxias" Cells 10, no. 4: 836. https://doi.org/10.3390/cells10040836

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