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Cells
Volume 10
Issue 4
10.3390/cells10040822
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Review

Ca2+ Signaling by TRPV4 Channels in Respiratory Function and Disease

by
Suhasini Rajan
,
Christian Schremmer
,
Jonas Weber
,
Philipp Alt
,
Fabienne Geiger
and
Alexander Dietrich
*
Experimental Pharmacotherapy, Walther-Straub-Institute of Pharmacology and Toxicology, Member of the German Center for Lung Research (DZL), LMU-Munich, 80336 Munich, Germany
*
Author to whom correspondence should be addressed.
Cells 2021, 10(4), 822; https://doi.org/10.3390/cells10040822
Submission received: 8 March 2021 / Revised: 23 March 2021 / Accepted: 4 April 2021 / Published: 6 April 2021
(This article belongs to the Special Issue Dysregulation of Calcium Signalling in Disease)
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Abstract

Members of the transient receptor potential (TRP) superfamily are broadly expressed in our body and contribute to multiple cellular functions. Most interestingly, the fourth member of the vanilloid family of TRP channels (TRPV4) serves different partially antagonistic functions in the respiratory system. This review highlights the role of TRPV4 channels in lung fibroblasts, the lung endothelium, as well as the alveolar and bronchial epithelium, during physiological and pathophysiological mechanisms. Data available from animal models and human tissues confirm the importance of this ion channel in cellular signal transduction complexes with Ca2+ ions as a second messenger. Moreover, TRPV4 is an excellent therapeutic target with numerous specific compounds regulating its activity in diseases, like asthma, lung fibrosis, edema, and infections.
Keywords: TRP channels; TRPV4; respiratory system; lung; endothelium; epithelium; Ca2+ signaling; signal transduction TRP channels; TRPV4; respiratory system; lung; endothelium; epithelium; Ca2+ signaling; signal transduction

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MDPI and ACS Style

Rajan, S.; Schremmer, C.; Weber, J.; Alt, P.; Geiger, F.; Dietrich, A. Ca2+ Signaling by TRPV4 Channels in Respiratory Function and Disease. Cells 2021, 10, 822. https://doi.org/10.3390/cells10040822

AMA Style

Rajan S, Schremmer C, Weber J, Alt P, Geiger F, Dietrich A. Ca2+ Signaling by TRPV4 Channels in Respiratory Function and Disease. Cells. 2021; 10(4):822. https://doi.org/10.3390/cells10040822

Chicago/Turabian Style

Rajan, Suhasini, Christian Schremmer, Jonas Weber, Philipp Alt, Fabienne Geiger, and Alexander Dietrich. 2021. "Ca2+ Signaling by TRPV4 Channels in Respiratory Function and Disease" Cells 10, no. 4: 822. https://doi.org/10.3390/cells10040822

APA Style

Rajan, S., Schremmer, C., Weber, J., Alt, P., Geiger, F., & Dietrich, A. (2021). Ca2+ Signaling by TRPV4 Channels in Respiratory Function and Disease. Cells, 10(4), 822. https://doi.org/10.3390/cells10040822

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