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Review

Rho GTPases in Skeletal Muscle Development and Homeostasis

by 1,2,3,4,* and 1,2,3
1
Molecular Mechanisms of Cancer Program, Centro de Investigación del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain
2
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain
3
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, 37007 Salamanca, Spain
4
Wellcome-MRC Institute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge CB2 0QQ, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Antonio Musarò
Cells 2021, 10(11), 2984; https://doi.org/10.3390/cells10112984
Received: 4 October 2021 / Revised: 29 October 2021 / Accepted: 29 October 2021 / Published: 2 November 2021
Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range of both cellular and physiological processes. In this review, we will summarize recent work on the role of Rho GTPase-regulated pathways in skeletal muscle development, regeneration, tissue mass homeostatic balance, and metabolism. In addition, we will present current evidence that links the dysregulation of these GTPases with diseases caused by skeletal muscle dysfunction. Overall, this information underscores the critical role of a number of members of the Rho GTPase subfamily in muscle development and the overall metabolic balance of mammalian species. View Full-Text
Keywords: small G protein; RhoA; Rac1; Cdc42; guanosine nucleotide exchange factors; GTPase activating proteins; rock; pak; signaling; myogenesis; muscle mass; muscle regeneration; satellite cells; metabolism small G protein; RhoA; Rac1; Cdc42; guanosine nucleotide exchange factors; GTPase activating proteins; rock; pak; signaling; myogenesis; muscle mass; muscle regeneration; satellite cells; metabolism
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MDPI and ACS Style

Rodríguez-Fdez, S.; Bustelo, X.R. Rho GTPases in Skeletal Muscle Development and Homeostasis. Cells 2021, 10, 2984. https://doi.org/10.3390/cells10112984

AMA Style

Rodríguez-Fdez S, Bustelo XR. Rho GTPases in Skeletal Muscle Development and Homeostasis. Cells. 2021; 10(11):2984. https://doi.org/10.3390/cells10112984

Chicago/Turabian Style

Rodríguez-Fdez, Sonia, and Xosé R. Bustelo. 2021. "Rho GTPases in Skeletal Muscle Development and Homeostasis" Cells 10, no. 11: 2984. https://doi.org/10.3390/cells10112984

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