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Article

Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study

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Department of Neurology, Mayo Clinic, Scottsdale, AZ 85251, USA
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Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
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Department of Neuropsychology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
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USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90007, USA
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Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
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Department of Neurology, Loma Linda University, Loma Linda, CA 92350, USA
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NeuroVision Imaging Inc., Sacramento, CA 95833, USA
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Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
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Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
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Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Maurice Ptito and Joseph Bouskila
Cells 2021, 10(11), 2926; https://doi.org/10.3390/cells10112926
Received: 29 June 2021 / Revised: 21 August 2021 / Accepted: 25 October 2021 / Published: 28 October 2021
(This article belongs to the Special Issue The Retina in Health and Disease)
Introduction: Retinal imaging is a non-invasive tool to study both retinal vasculature and neurodegeneration. In this exploratory retinal curcumin-fluorescence imaging (RFI) study, we sought to determine whether retinal vascular features combined with retinal amyloid burden correlate with the neurocognitive status. Methods: We used quantitative RFI in a cohort of patients with cognitive impairment to automatically compute retinal amyloid burden. Retinal blood vessels were segmented, and the vessel tortuosity index (VTI), inflection index, and branching angle were quantified. We assessed the correlations between retinal vascular and amyloid parameters, and cognitive domain Z-scores using linear regression models. Results: Thirty-four subjects were enrolled and twenty-nine (55% female, mean age 64 ± 6 years) were included in the combined retinal amyloid and vascular analysis. Eleven subjects had normal cognition and 18 had impaired cognition. Retinal VTI was discriminated among cognitive scores. The combined proximal mid-periphery amyloid count and venous VTI index exhibited significant differences between cognitively impaired and cognitively normal subjects (0.49 ± 1.1 vs. 0.91 ± 1.4, p = 0.006), and correlated with both the Wechsler Memory Scale-IV and SF-36 mental component score Z-scores (p < 0.05). Conclusion: This pilot study showed that retinal venular VTI combined with the proximal mid-periphery amyloid count could predict verbal memory loss. Future research is needed to finesse the clinical application of this retinal imaging-based technology. View Full-Text
Keywords: retinopathy; retinal vessels; retinal fluorescence imaging; amyloid; cognitive decline; Alzheimer’s disease retinopathy; retinal vessels; retinal fluorescence imaging; amyloid; cognitive decline; Alzheimer’s disease
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MDPI and ACS Style

Dumitrascu, O.M.; Rosenberry, R.; Sherman, D.S.; Khansari, M.M.; Sheyn, J.; Torbati, T.; Sherzai, A.; Sherzai, D.; Johnson, K.O.; Czeszynski, A.D.; Verdooner, S.; Black, K.L.; Frautschy, S.; Lyden, P.D.; Shi, Y.; Cheng, S.; Koronyo, Y.; Koronyo-Hamaoui, M. Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study. Cells 2021, 10, 2926. https://doi.org/10.3390/cells10112926

AMA Style

Dumitrascu OM, Rosenberry R, Sherman DS, Khansari MM, Sheyn J, Torbati T, Sherzai A, Sherzai D, Johnson KO, Czeszynski AD, Verdooner S, Black KL, Frautschy S, Lyden PD, Shi Y, Cheng S, Koronyo Y, Koronyo-Hamaoui M. Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study. Cells. 2021; 10(11):2926. https://doi.org/10.3390/cells10112926

Chicago/Turabian Style

Dumitrascu, Oana M., Ryan Rosenberry, Dale S. Sherman, Maziyar M. Khansari, Julia Sheyn, Tania Torbati, Ayesha Sherzai, Dean Sherzai, Kenneth O. Johnson, Alan D. Czeszynski, Steven Verdooner, Keith L. Black, Sally Frautschy, Patrick D. Lyden, Yonggang Shi, Susan Cheng, Yosef Koronyo, and Maya Koronyo-Hamaoui. 2021. "Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study" Cells 10, no. 11: 2926. https://doi.org/10.3390/cells10112926

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