TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel
Department of Neuroscience, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
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Cells 2021, 10(1), 165; https://doi.org/10.3390/cells10010165
Received: 3 December 2020 / Revised: 12 January 2021 / Accepted: 13 January 2021 / Published: 15 January 2021
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Ion Channels: From Development to Disease)
The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate array of stimuli, interacts with a multitude of proteins, and is modulated by a range of post-translational modifications, the majority of which we are only just beginning to understand. Not surprisingly, a great number of physiological roles have emerged for TRPV4, as have various disease states that are attributable to the absence, or abnormal functioning, of this ion channel. This review will highlight structural features of TRPV4, endogenous and exogenous activators of the channel, and discuss the reported roles of TRPV4 in health and disease.
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MDPI and ACS Style
Toft-Bertelsen, T.L.; MacAulay, N. TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel. Cells 2021, 10, 165. https://doi.org/10.3390/cells10010165
AMA Style
Toft-Bertelsen TL, MacAulay N. TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel. Cells. 2021; 10(1):165. https://doi.org/10.3390/cells10010165
Chicago/Turabian StyleToft-Bertelsen, Trine L.; MacAulay, Nanna. 2021. "TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel" Cells 10, no. 1: 165. https://doi.org/10.3390/cells10010165
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