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Cytoskeletal Regulation of Dermal Regeneration

Wound Healing Laboratory, Women's and Children's Health Research Institute, 72 King William Road, North Adelaide, South Australia 5006, Australia
Discipline of Paediatrics, University of Adelaide, South Australia 5005, Australia
Author to whom correspondence should be addressed.
Cells 2012, 1(4), 1313-1327;
Received: 31 August 2012 / Revised: 15 November 2012 / Accepted: 4 December 2012 / Published: 19 December 2012
(This article belongs to the Special Issue Tissue and Organ Regeneration)
PDF [684 KB, uploaded 19 December 2012]


Wound healing results in the repair of injured tissues however fibrosis and scar formation are, more often than not the unfortunate consequence of this process. The ability of lower order vertebrates and invertebrates to regenerate limbs and tissues has been all but lost in mammals; however, there are some instances where glimpses of mammalian regenerative capacity do exist. Here we describe the unlocked potential that exists in mammals that may help us understand the process of regeneration post-injury and highlight the potential role of the actin cytoskeleton in this process. The precise function and regulation of the cytoskeleton is critical to the success of the healing process and its manipulation may therefore facilitate regenerative healing. The gelsolin family of actin remodelling proteins in particular has been shown to have important functions in wound healing and family member Flightless I (Flii) is involved in both regeneration and repair. Understanding the interactions between different cytoskeletal proteins and their dynamic control of processes including cellular adhesion, contraction and motility may assist the development of therapeutics that will stimulate regeneration rather than repair. View Full-Text
Keywords: cytoskeleton; flightless I; gelsolin; skin regeneration; repair cytoskeleton; flightless I; gelsolin; skin regeneration; repair

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Strudwick, X.L.; Cowin, A.J. Cytoskeletal Regulation of Dermal Regeneration. Cells 2012, 1, 1313-1327.

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