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Polymers
Volume 16
Issue 4
10.3390/polym16040478
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Review

Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies

by
Wen-Nee Tan
1,*,
Benedict Anak Samling
1,2,
Woei-Yenn Tong
3,*,
Nelson Jeng-Yeou Chear
4,
Siti R. Yusof
4,
Jun-Wei Lim
5,6,
Joseph Tchamgoue
7,
Chean-Ring Leong
8 and
Surash Ramanathan
4
1
Chemistry Section, School of Distance Education, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia
2
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan 94300, Sarawak, Malaysia
3
Institute of Medical Science Technology, Universiti Kuala Lumpur, Kajang 43000, Selangor, Malaysia
4
Centre for Drug Research, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia
5
HICoE-Centre for Biofuel and Biochemical Research, Institute of Self-Sustainable Building, Department of Fundamental and Applied Sciences, Universiti Teknologi PETRONAS, Seri Iskandar 32610, Perak Darul Ridzuan, Malaysia
6
Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, India
7
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon
8
Branch Campus Malaysian Institute of Chemical and Bioengineering Technology, Universiti Kuala Lumpur, Alor Gajah 78000, Melaka, Malaysia
*
Authors to whom correspondence should be addressed.
Polymers 2024, 16(4), 478; https://doi.org/10.3390/polym16040478
Submission received: 26 December 2023 / Revised: 31 January 2024 / Accepted: 5 February 2024 / Published: 8 February 2024
(This article belongs to the Special Issue Research Progress on Chitosan Applications)
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Abstract

Since ancient times, essential oils (EOs) derived from aromatic plants have played a significant role in promoting human health. EOs are widely used in biomedical applications due to their medicinal properties. EOs and their constituents have been extensively studied for treating various health-related disorders, including cancer. Nonetheless, their biomedical applications are limited due to several drawbacks. Recent advances in nanotechnology offer the potential for utilising EO-loaded nanoparticles in the treatment of various diseases. In this aspect, chitosan (CS) appears as an exceptional encapsulating agent owing to its beneficial attributes. This review highlights the use of bioactive EOs and their constituents against breast cancer cells. Challenges associated with the use of EOs in biomedical applications are addressed. Essential information on the benefits of CS as an encapsulant, the advantages of nanoencapsulated EOs, and the cytotoxic actions of CS-based nanoencapsulated EOs against breast cancer cells is emphasised. Overall, the nanodelivery of bioactive EOs employing polymeric CS represents a promising avenue against breast cancer cells in preclinical studies.
Keywords: breast cancer; chitosan; drug delivery; nanoencapsulated essential oils; therapeutics breast cancer; chitosan; drug delivery; nanoencapsulated essential oils; therapeutics

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MDPI and ACS Style

Tan, W.-N.; Samling, B.A.; Tong, W.-Y.; Chear, N.J.-Y.; Yusof, S.R.; Lim, J.-W.; Tchamgoue, J.; Leong, C.-R.; Ramanathan, S. Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies. Polymers 2024, 16, 478. https://doi.org/10.3390/polym16040478

AMA Style

Tan W-N, Samling BA, Tong W-Y, Chear NJ-Y, Yusof SR, Lim J-W, Tchamgoue J, Leong C-R, Ramanathan S. Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies. Polymers. 2024; 16(4):478. https://doi.org/10.3390/polym16040478

Chicago/Turabian Style

Tan, Wen-Nee, Benedict Anak Samling, Woei-Yenn Tong, Nelson Jeng-Yeou Chear, Siti R. Yusof, Jun-Wei Lim, Joseph Tchamgoue, Chean-Ring Leong, and Surash Ramanathan. 2024. "Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies" Polymers 16, no. 4: 478. https://doi.org/10.3390/polym16040478

APA Style

Tan, W.-N., Samling, B. A., Tong, W.-Y., Chear, N. J.-Y., Yusof, S. R., Lim, J.-W., Tchamgoue, J., Leong, C.-R., & Ramanathan, S. (2024). Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies. Polymers, 16(4), 478. https://doi.org/10.3390/polym16040478

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