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Polymers
Volume 16
Issue 13
10.3390/polym16131932
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Article

3D-Bioprinted Gelatin Methacryloyl-Strontium-Doped Hydroxyapatite Composite Hydrogels Scaffolds for Bone Tissue Regeneration

by
Cosmin Iulian Codrea
1,2,
Dilruba Baykara
3,4,
Raul-Augustin Mitran
2,
Ayşe Ceren Çalıkoğlu Koyuncu
3,4,
Oguzhan Gunduz
3,4,* and
Anton Ficai
1,5,6,7,*
1
Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica of Bucharest, 060042 Bucharest, Romania
2
Institute of Physical Chemistry “Ilie Murgulescu” of the Romanian Academy, 060021 Bucharest, Romania
3
Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, 34722 Istanbul, Turkey
4
Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, 34722 Istanbul, Turkey
5
National Research Center for Micro and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania
6
National Centre for Food Safety, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania
7
Academy of Romanian Scientists, Ilfov St. 3, 50044 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Polymers 2024, 16(13), 1932; https://doi.org/10.3390/polym16131932
Submission received: 3 June 2024 / Revised: 26 June 2024 / Accepted: 3 July 2024 / Published: 6 July 2024
(This article belongs to the Special Issue Polymeric Materials and Their Application in 3D Printing, 2nd Edition)
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Abstract

New gelatin methacryloyl (GelMA)—strontium-doped nanosize hydroxyapatite (SrHA) composite hydrogel scaffolds were developed using UV photo-crosslinking and 3D printing for bone tissue regeneration, with the controlled delivery capacity of strontium (Sr). While Sr is an effective anti-osteoporotic agent with both anti-resorptive and anabolic properties, it has several important side effects when systemic administration is applied. Multi-layer composite scaffolds for bone tissue regeneration were developed based on the digital light processing (DLP) 3D printing technique through the photopolymerization of GelMA. The chemical, morphological, and biocompatibility properties of these scaffolds were investigated. The composite gels were shown to be suitable for 3D printing. In vitro cell culture showed that osteoblasts can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-SrHA hydrogel has good cell viability and biocompatibility. The GelMA-SrHA composites are promising 3D-printed scaffolds for bone repair.
Keywords: hydroxyapatite; precipitation; hydrothermal; strontium; gelatin methacryloyl; 3D-printing; digital light processing; bioactivity hydroxyapatite; precipitation; hydrothermal; strontium; gelatin methacryloyl; 3D-printing; digital light processing; bioactivity

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MDPI and ACS Style

Codrea, C.I.; Baykara, D.; Mitran, R.-A.; Koyuncu, A.C.Ç.; Gunduz, O.; Ficai, A. 3D-Bioprinted Gelatin Methacryloyl-Strontium-Doped Hydroxyapatite Composite Hydrogels Scaffolds for Bone Tissue Regeneration. Polymers 2024, 16, 1932. https://doi.org/10.3390/polym16131932

AMA Style

Codrea CI, Baykara D, Mitran R-A, Koyuncu ACÇ, Gunduz O, Ficai A. 3D-Bioprinted Gelatin Methacryloyl-Strontium-Doped Hydroxyapatite Composite Hydrogels Scaffolds for Bone Tissue Regeneration. Polymers. 2024; 16(13):1932. https://doi.org/10.3390/polym16131932

Chicago/Turabian Style

Codrea, Cosmin Iulian, Dilruba Baykara, Raul-Augustin Mitran, Ayşe Ceren Çalıkoğlu Koyuncu, Oguzhan Gunduz, and Anton Ficai. 2024. "3D-Bioprinted Gelatin Methacryloyl-Strontium-Doped Hydroxyapatite Composite Hydrogels Scaffolds for Bone Tissue Regeneration" Polymers 16, no. 13: 1932. https://doi.org/10.3390/polym16131932

APA Style

Codrea, C. I., Baykara, D., Mitran, R.-A., Koyuncu, A. C. Ç., Gunduz, O., & Ficai, A. (2024). 3D-Bioprinted Gelatin Methacryloyl-Strontium-Doped Hydroxyapatite Composite Hydrogels Scaffolds for Bone Tissue Regeneration. Polymers, 16(13), 1932. https://doi.org/10.3390/polym16131932

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