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Open AccessArticle

Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage

1
Department of Mechanical Engineering, College of Mechanical & Electrical Engineering, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan
2
Department of Orthopedics, Taipei City Hospital, Renai Branch, Taipei 10629, Taiwan
3
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan
4
Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(12), 1971; https://doi.org/10.3390/polym11121971
Received: 29 October 2019 / Revised: 26 November 2019 / Accepted: 28 November 2019 / Published: 30 November 2019
(This article belongs to the Special Issue Medical Application of Polymer-Based Composites)
Kyphoplasty is an important treatment for stabilizing spine fractures due to osteoporosis. However, leakage of polymethyl-methacrylate (PMMA) bone cement during this procedure into the spinal canal has been reported to cause many adverse effects. In this study, we prepared an implantable membrane to serve as a barrier that avoids PMMA cement leakage during kyphoplasty procedures through a hybrid composite made of poly-l-lactic acid (PLLA) and tricalcium silicate (C3S), with the addition of C3S into PLLA matrix, showing enhanced mechanical and anti-degradation properties while keeping good cytocompatibility when compared to PLLA alone and most importantly, when this material design was applied under standardized PMMA cement injection conditions, no posterior wall leakage was observed after the kyphoplasty procedure in pig lumbar vertebral bone models. Testing results assess its effectiveness for clinical practice. View Full-Text
Keywords: kyphoplasty; polymethyl-methacrylate bone cement; barrier; poly-l-lactic acid; tricalcium silicate kyphoplasty; polymethyl-methacrylate bone cement; barrier; poly-l-lactic acid; tricalcium silicate
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Leu, T.-H.; Wei, Y.; Hwua, Y.-S.; Huang, X.-J.; Huang, J.-T.; Chung, R.-J. Fabrication of PLLA/C3S Composite Membrane for the Prevention of Bone Cement Leakage. Polymers 2019, 11, 1971.

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