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Proton Radiotherapy for Pediatric Sarcoma

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Author to whom correspondence should be addressed.
Cancers 2014, 6(1), 112-127;
Received: 20 October 2013 / Revised: 17 December 2013 / Accepted: 18 December 2013 / Published: 14 January 2014
(This article belongs to the Special Issue Soft Tissue and Bone Sarcoma)
PDF [659 KB, uploaded 14 January 2014]


Pediatric sarcomas represent a distinct group of pathologies, with approximately 900 new cases per year in the United States alone. Radiotherapy plays an integral role in the local control of these tumors, which often arise adjacent to critical structures and growing organs. The physical properties of proton beam radiotherapy provide a distinct advantage over standard photon radiation by eliminating excess dose deposited beyond the target volume, thereby reducing both the dose of radiation delivered to non-target structures as well as the total radiation dose delivered to a patient. Dosimetric studies comparing proton plans to IMRT and 3D conformal radiation have demonstrated the superiority of protons in numerous pediatric malignancies and data on long-term clinical outcomes and toxicity is emerging. In this article, we review the existing clinical and dosimetric data regarding the use of proton beam radiation in malignant bone and soft tissue sarcomas. View Full-Text
Keywords: sarcoma; pediatrics; protons; ewings; osteosarcoma; rhabdomyosarcoma; chordoma; chondrosarcoma sarcoma; pediatrics; protons; ewings; osteosarcoma; rhabdomyosarcoma; chordoma; chondrosarcoma

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Ladra, M.M.; Yock, T.I. Proton Radiotherapy for Pediatric Sarcoma. Cancers 2014, 6, 112-127.

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