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TRAF4, at the Crossroad between Morphogenesis and Cancer

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR 7104 CNRS, U964 INSERM, Université de Strasbourg, BP 10142, 67404 Illkirch, C.U. de Strasbourg, France
Author to whom correspondence should be addressed.
Cancers 2011, 3(2), 2734-2749;
Received: 12 May 2011 / Revised: 16 June 2011 / Accepted: 17 June 2011 / Published: 21 June 2011
(This article belongs to the Special Issue Cancer Diagnosis and Targeted Therapy)
PDF [482 KB, uploaded 21 June 2011]


Tumor Necrosis Factor Receptor-Associated Factor 4 (TRAF4) is a gene whose expression is altered in cancers. It is overexpressed in a variety of carcinomas of different origins, often as a consequence of amplification. TRAF4 encodes an adaptor protein that belongs to the TRAF protein family. While most TRAF proteins influence immune and inflammation processes, TRAF4 is mainly involved in developmental and morphogenic processes. Interestingly, this protein has been shown to be linked to crucial cellular functions such as cell polarity and the regulation of reactive oxygen species production. View Full-Text
Keywords: TRAF; reactive oxygen species; cell polarity; morphogenesis; cancerogenesis; smurf TRAF; reactive oxygen species; cell polarity; morphogenesis; cancerogenesis; smurf

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Rousseau, A.; Rio, M.-C.; Alpy, F. TRAF4, at the Crossroad between Morphogenesis and Cancer. Cancers 2011, 3, 2734-2749.

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