Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review
Abstract
Simple Summary
Abstract
1. Introduction
2. Epidemiology of Oral Cancer
3. How Many Oral Cancers Are Preceded by an OPMD?
4. How Many OPMDs Will Become Cancers?
Disease | CMTR | AMTR | n. of Patients | Ref. |
---|---|---|---|---|
Proliferative leukoplakia | 45.8% | 6.36% | 699 | [38] |
Erythroplakia | 12.7% | 1.91% | 441 | [40] |
Leukoplakia | 9.7% | 1.35% | 23,489 | [43] |
Oral submucous fibrosis | 4.2% | 0.73% | 6337 | [44] |
Oral lichen planus | 0.94% | 0.28% [35] | 22,578 | [49] |
Oral lichenoid lesions # | 1.95% | 0.35% [55] | 717 | [49] |
Actinic keratosis/cheilitis ## | 14% | 1.69% [56] | 728 | [57] |
Chronic hyperplastic candidiasis ## | 12.1% | 1.51% | 274 | [58] |
5. Overdiagnosis of OPMDs
6. Conclusions
Funding
Conflicts of Interest
References
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Global Burden of Disease 2019 | GLOBOCAN 2020 | |||
---|---|---|---|---|
ICD-10 Codes | ASIR (95% UI) | ASMR (95% UI) | ASIR | ASMR |
Lip and oral cavity (C00–06) | 7.1 (6.5–7.7) | 3.8 (3.5–4.2) | 4.1 | 1.9 |
Salivary glands (C07, C08) | 0.57 | 0.23 | ||
Oropharynx (C09, C10) | 3.2 (2.9–3.4) | 2.2 (2.0–2.4) | 1.1 | 0.51 |
Hypopharynx (C12, C13) | 0.91 | 0.41 |
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Cirillo, N. Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review. Cancers 2024, 16, 1550. https://doi.org/10.3390/cancers16081550
Cirillo N. Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review. Cancers. 2024; 16(8):1550. https://doi.org/10.3390/cancers16081550
Chicago/Turabian StyleCirillo, Nicola. 2024. "Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review" Cancers 16, no. 8: 1550. https://doi.org/10.3390/cancers16081550
APA StyleCirillo, N. (2024). Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review. Cancers, 16(8), 1550. https://doi.org/10.3390/cancers16081550