Next Article in Journal
Prognostic Discrimination of Alternative Lymph Node Classification Systems for Patients with Radically Resected Non-Metastatic Colorectal Cancer: A Cohort Study from a Single Tertiary Referral Center
Next Article in Special Issue
Midterm MRI Follow-Up of Untreated Enchondroma and Atypical Cartilaginous Tumors in the Long Bones
Previous Article in Journal
Irreversible Electroporation and Nivolumab Combined with Intratumoral Administration of a Toll-Like Receptor Ligand, as a Means of In Vivo Vaccination for Metastatic Pancreatic Ductal Adenocarcinoma (PANFIRE-III). A Phase-I Study Protocol
Previous Article in Special Issue
Pleuropneumonectomy as Salvage Therapy in Children Suffering from Primary or Metastatic Sarcomas with Pleural Localizations
Article

Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study

1
Department of Orthopedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan
2
Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
3
Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8570, Japan
4
Department of Orthopaedic Surgery, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan
5
Division of Orthopaedic Surgery, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan
6
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences University of Fukui, Fukui 910-1193, Japan
7
Department of Orthopaedic Surgery, Fujita Medical University, Toyoake 470-1192, Japan
8
Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
9
Department of Orthopaedic Surgery, Hamamatsu Medical University, Hamamatsu 431-3125, Japan
10
Department of Orthopaedic Surgery, Nagoya Memorial Hospital, Nagoya 468-8250, Japan
11
Department of Orthopedic Oncology, Okazaki City Hospital, Okazaki 444-8553, Japan
12
Division of Orthopaedic Oncology, Shizuoka Cancer Center Hospital, Nagaizumi 411-0934, Japan
13
Department of Rehabilitation, Nagoya University Hospital, Nagoya 466-8560, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: François Lamoureux
Cancers 2021, 13(15), 3901; https://doi.org/10.3390/cancers13153901
Received: 1 July 2021 / Revised: 27 July 2021 / Accepted: 28 July 2021 / Published: 2 August 2021
(This article belongs to the Special Issue Diagnosis and Treatment for Bone Tumor and Sarcoma)
It is essential to focus on the tumor invasive front (tail-like lesion)—the soft tissue sarcoma’s specific peripheral infiltrative growth characteristics—to avoid leaving unexpected tumor residues during surgery. This study aimed to analyze the effect of neoadjuvant therapy for highly malignant soft tissue tumors with tail-like lesions. From 2012 to 2019, 36 patients were treated with neoadjuvant therapy, including chemotherapy, radiotherapy, or both. Consequently, we observed shrinkage, and occasionally the disappearance of the tail-like lesion. The lesion’s regression was related to the necrosis rate of the main part of the tumor. However, the regression of lesions was not directly related to the achievement of surgery with a microscopically negative margin or improvements of oncological outcomes. Thus, a more multi-angle evaluation to elaborate surgical strategy is necessary.
Several types of soft tissue sarcomas have peripheral infiltrative growth characteristics called tail-like lesions. The efficacy of neoadjuvant therapy for tumors with tail-like lesions has not been elucidated. From 2012 to 2019, we analyzed 36 patients with soft tissue sarcoma with tail-like lesions treated with neoadjuvant therapy, including chemotherapy, radiotherapy, or both. The effect of neoadjuvant therapy on the tail sign was investigated by analyzing the change in tail-like lesions during neoadjuvant therapy and histological responses. The median length of the tail-like lesion reduced from 29.5 mm at initiation to 19.5 mm after neoadjuvant therapy. The extent of shrinkage in tail-like lesions was related to the histopathological responses in the main part of the tumor. Complete disappearance of the tail-like lesion was observed in 12 patients; however, it was not related to achieving a microscopically negative margin. The oncologic outcomes did not significantly differ between cases with and without the complete disappearance of tail-like lesions. This study indicated that the shrinkage of tail-like lesions did not have a significant effect on complete resection or improvements of clinical outcomes. A more comprehensive evaluation is needed to elaborate on the surgical strategy. View Full-Text
Keywords: soft tissue sarcoma; invasive front; tail-like lesion; myxofibrosarcoma; undifferentiated pleomorphic sarcoma; neoadjuvant therapy; radiotherapy; chemotherapy soft tissue sarcoma; invasive front; tail-like lesion; myxofibrosarcoma; undifferentiated pleomorphic sarcoma; neoadjuvant therapy; radiotherapy; chemotherapy
Show Figures

Figure 1

MDPI and ACS Style

Aiba, H.; Ikuta, K.; Asanuma, K.; Kawanami, K.; Tsukushi, S.; Matsumine, A.; Ishimura, D.; Nagano, A.; Shido, Y.; Kozawa, E.; Yamada, K.; Wasa, J.; Kimura, H.; Sakai, T.; Murakami, H.; Sakai, T.; Nakamura, T.; Nishida, Y. Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study. Cancers 2021, 13, 3901. https://doi.org/10.3390/cancers13153901

AMA Style

Aiba H, Ikuta K, Asanuma K, Kawanami K, Tsukushi S, Matsumine A, Ishimura D, Nagano A, Shido Y, Kozawa E, Yamada K, Wasa J, Kimura H, Sakai T, Murakami H, Sakai T, Nakamura T, Nishida Y. Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study. Cancers. 2021; 13(15):3901. https://doi.org/10.3390/cancers13153901

Chicago/Turabian Style

Aiba, Hisaki, Kunihiro Ikuta, Kunihiro Asanuma, Katsuhisa Kawanami, Satoshi Tsukushi, Akihiko Matsumine, Daisuke Ishimura, Akihito Nagano, Yoji Shido, Eiji Kozawa, Kenji Yamada, Junji Wasa, Hiroaki Kimura, Takao Sakai, Hideki Murakami, Tomohisa Sakai, Tomoki Nakamura, and Yoshihiro Nishida. 2021. "Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study" Cancers 13, no. 15: 3901. https://doi.org/10.3390/cancers13153901

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop