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Incidence, Therapy, and Bleeding Risk—Cancer- Associated Thrombosis in Patients with Glioblastoma

Division of Vascular Medicine, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
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Author to whom correspondence should be addressed.
Cancers 2020, 12(6), 1354; https://doi.org/10.3390/cancers12061354
Received: 4 May 2020 / Revised: 21 May 2020 / Accepted: 24 May 2020 / Published: 26 May 2020
(This article belongs to the Special Issue Treatment of Cancer-Associated Thrombosis)
Cancer is an independent risk factor for the development of venous thromboembolism (VTE). Glioblastomas are amongst cancer types with the most thrombogenic potential and patients are at a particularly high risk of VTE with an incidence up to 20–30% per year. Currently, major efforts are underway to gain novel insights into risk factors and pathomechanisms to provide a better understanding of development of VTE in patients with primary brain tumors. Treatment of VTE requires therapeutic anticoagulation, which accordingly to recently-published guidelines should be performed using low molecular weight heparin or, in case of low bleeding risk, using a direct oral anticoagulant. However, this can be very challenging due to an increased risk of intracranial hemorrhage in this patient group. Furthermore, limited data are available on the subgroup of patients with primary brain tumors. View Full-Text
Keywords: venous thromboembolism; glioblastoma; cancer-associated thrombosis; anticoagulation; risk factors; treatment venous thromboembolism; glioblastoma; cancer-associated thrombosis; anticoagulation; risk factors; treatment
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Muster, V.; Gary, T. Incidence, Therapy, and Bleeding Risk—Cancer- Associated Thrombosis in Patients with Glioblastoma. Cancers 2020, 12, 1354.

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