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Article

The Possible Influence of Mediterranean Diet on Extracellular Vesicle miRNA Expression in Breast Cancer Survivors

1
Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, 363 Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do 16995, Korea
2
National Institute of Nursing Research, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
3
College of Nursing, University of Iowa, 485 CNB 50 Newton Rd., Iowa City, IA 52245, USA
4
Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital 211, Eonju-ro, Gangnam-gu, Seoul 06273, Korea
5
Yotta Biomed, LLC, 8908 Ewing Dr., Bethesda, MD 20817, USA
6
College of Nursing, Yonsei University, Mo-Im Kim Nursing Research Institute, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
*
Authors to whom correspondence should be addressed.
These authors are co-first authors who equally contributed to this work.
Cancers 2020, 12(6), 1355; https://doi.org/10.3390/cancers12061355
Received: 17 April 2020 / Revised: 15 May 2020 / Accepted: 22 May 2020 / Published: 26 May 2020
(This article belongs to the Special Issue MicroRNA Therapeutics: Towards a New Era for the Management of Cancer)
The Mediterranean diet (MD) has been reported to have beneficial effects on breast cancer and cardiovascular diseases. Recently, microRNAs (miRNAs) have been suggested as biomarkers for the diagnosis and disease prognosis in cancer and cardiovascular diseases. We evaluated the influence of the MD on the plasma-derived extracellular vesicle miRNA signature of overweight breast cancer survivors. Sixteen participants instructed to adhere to the MD for eight weeks were included in this study. To curate differentially expressed miRNAs after MD intervention, we employed two methods: significance analysis of microarrays and DESeq2. The selected miRNAs were analyzed using ingenuity pathway analysis. After an eight-week intervention, body mass index, waist circumference, fasting glucose, fasting insulin, and homeostatic model assessment for insulin resistance were significantly improved. Expression levels of 798 miRNAs were comprehensively analyzed, and 42 extracellular vesicle miRNAs were significantly differentially regulated after the eight-week MD (36 were up and 6 were down-regulated). We also identified enriched pathways in genes regulated by differentially expressed 42 miRNAs, which include signaling associated with breast cancer, energy metabolism, glucose metabolism, and insulin. Our study indicates that extracellular vesicle miRNAs differentially expressed as a result of the MD might be involved in the mechanisms that relate to cardiometabolic risk factors in overweight breast cancer survivors. View Full-Text
Keywords: mediterranean diet; breast cancer survivor; microRNA; obesity mediterranean diet; breast cancer survivor; microRNA; obesity
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MDPI and ACS Style

Kwon, Y.-J.; Cho, Y.-E.; Cho, A.-R.; Choi, W.J.; Yun, S.; Park, H.; Kim, H.-S.; Cashion, A.K.; Gill, J.; Lee, H.; Lee, J.-W. The Possible Influence of Mediterranean Diet on Extracellular Vesicle miRNA Expression in Breast Cancer Survivors. Cancers 2020, 12, 1355. https://doi.org/10.3390/cancers12061355

AMA Style

Kwon Y-J, Cho Y-E, Cho A-R, Choi WJ, Yun S, Park H, Kim H-S, Cashion AK, Gill J, Lee H, Lee J-W. The Possible Influence of Mediterranean Diet on Extracellular Vesicle miRNA Expression in Breast Cancer Survivors. Cancers. 2020; 12(6):1355. https://doi.org/10.3390/cancers12061355

Chicago/Turabian Style

Kwon, Yu-Jin, Young-Eun Cho, A-Ra Cho, Won J. Choi, Sijung Yun, Hyunki Park, Hyung-Suk Kim, Ann K. Cashion, Jessica Gill, Hyangkyu Lee, and Ji-Won Lee. 2020. "The Possible Influence of Mediterranean Diet on Extracellular Vesicle miRNA Expression in Breast Cancer Survivors" Cancers 12, no. 6: 1355. https://doi.org/10.3390/cancers12061355

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