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Open AccessArticle

Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas

1
Department of Neurosurgery, University Hospital Tübingen, 72076 Tübingen, BW, Germany
2
Centre of Neurofibromatosis and Rare Diseases, University Hospital Tübingen, 72076 Tübingen, BW, Germany
3
Division of Pediatric Neurosurgery, University Hospital Tübingen, 72076 Tübingen, BW, Germany
4
Department of Neurology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, HH, Germany
5
Department of Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, HH, Germany
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(9), 1376; https://doi.org/10.3390/cancers11091376
Received: 28 July 2019 / Revised: 29 August 2019 / Accepted: 11 September 2019 / Published: 16 September 2019
(This article belongs to the Special Issue New Insights into Neurofibromatosis)
Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively reviewed hearing and volumetry data sets of 39 operated tumors (ears) in 23 patients under the age of 25 and in a follow-up period of 21 to 167 months. Hearing data over a compatible period on 20 other tumors, which did not receive surgery due to their less aggressive nature, were included for comparison. Surgery was carried out via a retrosigmoid approach with the brainstem auditory evoked potential (BAEP) guide. Immediately after surgery, functional hearing was maintained in 82% of ears. Average hearing scores were better in the non-surgery ears. However, the hearing scores in both groups worsened gradually with a similar dynamic during the 42-month postoperative follow-up period. No accelerated impairment of hearing was evident for the operated cases. Rather, the gap between the two hearing deterioration lines tended to close at the end of the follow-up period. Our result suggested that the BAEP-guided surgery did not cause additional hearing deterioration in the long-term and seemed to slow down hearing deterioration of those tumors that were initially more aggressive. View Full-Text
Keywords: brainstem auditory evoked potentials; facial nerve; hearing preservation; neurofibromatosis type 2; surgery; vestibular schwannoma brainstem auditory evoked potentials; facial nerve; hearing preservation; neurofibromatosis type 2; surgery; vestibular schwannoma
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Gugel, I.; Grimm, F.; Liebsch, M.; Zipfel, J.; Teuber, C.; Kluwe, L.; Mautner, V.-F.; Tatagiba, M.; Schuhmann, M.U. Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas. Cancers 2019, 11, 1376.

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