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Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer

Department of Biology, University of Naples ‘Federico II’, 80126 Naples, Italy
Department of Molecular Medicine and Medical Biotechnologies, University of Naples, ‘Federico II’, 80131 Naples, Italy
Author to whom correspondence should be addressed.
Cancers 2019, 11(3), 324;
Received: 31 January 2019 / Revised: 25 February 2019 / Accepted: 4 March 2019 / Published: 7 March 2019
(This article belongs to the Collection Histone Modification in Cancer)
PDF [4296 KB, uploaded 13 March 2019]


Studies of alterations in histone methylation in cancer have led to the identification of histone methyltransferases and demethylases as novel targets for therapy. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), demethylates H3K4me1/2, or H3K9me1/2 in a context-dependent manner. In addition to the well-studied role of LSD1 in the epigenetic regulation of histone methylation changes, LSD1 regulates the methylation dynamic of several non-histone proteins and participates in the assembly of different long noncoding RNA (lncRNA_ complexes. LSD1 is highly expressed in various cancers, playing a pivotal role in different cancer-related processes. Here, we summarized recent findings on the role of LSD1 in the regulation of different biological processes in cancer cells through dynamic methylation of non-histone proteins and physical association with dedicated lncRNA. View Full-Text
Keywords: LSD1; epigenetics; histone demethylase; cancer; lncRNAs LSD1; epigenetics; histone demethylase; cancer; lncRNAs

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Majello, B.; Gorini, F.; Saccà, C.D.; Amente, S. Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer. Cancers 2019, 11, 324.

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