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Open AccessArticle

Catecholamines Induce Left Ventricular Subclinical Systolic Dysfunction: A Speckle-Tracking Echocardiography Study

1
3rd Department of Medicine, Centre for Hypertension, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Ovocný trh 5, 116 36 Prague 1, Czech Republic
2
Department of Nephrology, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Ovocný trh 5, 116 36 Prague 1, Czech Republic
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(3), 318; https://doi.org/10.3390/cancers11030318
Received: 9 January 2019 / Revised: 24 February 2019 / Accepted: 28 February 2019 / Published: 6 March 2019
(This article belongs to the Special Issue Pheochromocytoma (PHEO) and Paraganglioma (PGL))
Background: Pheochromocytomas (PHEO) are tumors arising from chromaffin cells from the adrenal medulla, having the ability to produce, metabolize and secrete catecholamines. The overproduction of catecholamines leads by many mechanisms to the impairment in the left ventricle (LV) function, however, endocardial measurement of systolic function did not find any differences between patients with PHEO and essential hypertension (EH). The aim of the study was to investigate whether global longitudinal strain (GLS) derived from speckle-tracking echocardiography can detect catecholamine-induced subclinical impairments in systolic function. Methods: We analyzed 17 patients (10 females and seven males) with PHEO and 18 patients (nine females and nine males) with EH. The groups did not differ in age or in 24-h blood pressure values. Results: The patients with PHEO did not differ in echocardiographic parameters including LV ejection fraction compared to the EH patients (0.69 ± 0.04 vs. 0.71 ± 0.05; NS), nevertheless, in spackle-tracking analysis, the patients with PHEO displayed significantly lower GLS than the EH patients (−14.8 ± 1.5 vs. −17.8 ± 1.7; p < 0.001). Conclusions: Patients with PHEO have a lower magnitude of GLS than the patients with EH, suggesting that catecholamines induce a subclinical decline in LV systolic function. View Full-Text
Keywords: pheochromocytoma; catecholamine; global longitudinal strain; speckle-tracking echocardiography; subclinical systolic dysfunction pheochromocytoma; catecholamine; global longitudinal strain; speckle-tracking echocardiography; subclinical systolic dysfunction
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Kvasnička, J.; Zelinka, T.; Petrák, O.; Rosa, J.; Štrauch, B.; Krátká, Z.; Indra, T.; Markvartová, A.; Widimský, J., Jr.; Holaj, R. Catecholamines Induce Left Ventricular Subclinical Systolic Dysfunction: A Speckle-Tracking Echocardiography Study. Cancers 2019, 11, 318.

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