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TYK2: An Upstream Kinase of STATs in Cancer

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria
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Author to whom correspondence should be addressed.
Cancers 2019, 11(11), 1728; https://doi.org/10.3390/cancers11111728
Received: 30 September 2019 / Revised: 28 October 2019 / Accepted: 2 November 2019 / Published: 5 November 2019
(This article belongs to the Special Issue Targeting STAT3 and STAT5 in Cancer)
In this review we concentrate on the recent findings describing the oncogenic potential of the protein tyrosine kinase 2 (TYK2). The overview on the current understanding of TYK2 functions in cytokine responses and carcinogenesis focusses on the activation of the signal transducers and activators of transcription (STAT) 3 and 5. Insight gained from loss-of-function (LOF) gene-modified mice and human patients homozygous for Tyk2/TYK2-mutated alleles established the central role in immunological and inflammatory responses. For the description of physiological TYK2 structure/function relationships in cytokine signaling and of overarching molecular and pathologic properties in carcinogenesis, we mainly refer to the most recent reviews. Dysregulated TYK2 activation, aberrant TYK2 protein levels, and gain-of-function (GOF) TYK2 mutations are found in various cancers. We discuss the molecular consequences thereof and briefly describe the molecular means to counteract TYK2 activity under (patho-)physiological conditions by cellular effectors and by pharmacological intervention. For the role of TYK2 in tumor immune-surveillance we refer to the recent Special Issue of Cancers “JAK-STAT Signaling Pathway in Cancer”. View Full-Text
Keywords: tyrosine kinase 2; JAK family of protein tyrosine kinases; signal transducer and activator of transcription; cytokine receptor signaling; gain-of-function mutation; tumorigenesis tyrosine kinase 2; JAK family of protein tyrosine kinases; signal transducer and activator of transcription; cytokine receptor signaling; gain-of-function mutation; tumorigenesis
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MDPI and ACS Style

Wöss, K.; Simonović, N.; Strobl, B.; Macho-Maschler, S.; Müller, M. TYK2: An Upstream Kinase of STATs in Cancer. Cancers 2019, 11, 1728.

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