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Open AccessReview

Oncolytic Viruses as Therapeutic Tools for Pediatric Brain Tumors

1
The Health Research Institute of Navarra (IDISNA), 31008 Pamplona, Spain
2
Department of Pediatrics, University Hospital of Navarra, 31008 Pamplona, Spain
3
Department of Neurosurgery, University Hospital of Navarra, 31008 Pamplona, Spain
4
Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
5
Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Program in Solid Tumors and Biomarkers, Foundation for the Applied Medical Research, Pamplona, Spain.
Cancers 2018, 10(7), 226; https://doi.org/10.3390/cancers10070226
Received: 28 June 2018 / Accepted: 4 July 2018 / Published: 9 July 2018
(This article belongs to the Special Issue Oncolytic Virotherapy)
In recent years, we have seen an important progress in our comprehension of the molecular basis of pediatric brain tumors (PBTs). However, they still represent the main cause of death by disease in children. Due to the poor prognosis of some types of PBTs and the long-term adverse effects associated with the traditional treatments, oncolytic viruses (OVs) have emerged as an interesting therapeutic option since they displayed safety and high tolerability in pre-clinical and clinical levels. In this review, we summarize the OVs evaluated in different types of PBTs, mostly in pre-clinical studies, and we discuss the possible future direction of research in this field. In this sense, one important aspect of OVs antitumoral effect is the stimulation of an immune response against the tumor which is necessary for a complete response in preclinical immunocompetent models and in the clinic. The role of the immune system in the response of OVs needs to be evaluated in PBTs and represents an experimental challenge due to the limited immunocompetent models of these diseases available for pre-clinical research. View Full-Text
Keywords: oncolytic virus; pediatric brain tumors; immunostimulation oncolytic virus; pediatric brain tumors; immunostimulation
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Varela-Guruceaga, M.; Tejada-Solís, S.; García-Moure, M.; Fueyo, J.; Gomez-Manzano, C.; Patiño-García, A.; Alonso, M.M. Oncolytic Viruses as Therapeutic Tools for Pediatric Brain Tumors. Cancers 2018, 10, 226.

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